Use of statins after liver transplantation is associated with improved survival: results of a nationwide study. Issue 7 (18th August 2022)

• Record Type: Journal Article
• Authors: Becchetti, Chiara; Dirchwolf, Melisa; Schropp, Jonas; Magini, Giulia; Müllhaupt, Beat; Immer, Franz; Dufour, Jean‐François; Banz, Vanessa; Berzigotti, Annalisa; Bosch, Jaume
• Other Names: Amico Patrizia investigator.; Axel Andres investigator.; Aubert John‐David investigator.; Banz Vanessa investigator.; Sonja Beckmann investigator.; Beldi Guido investigator.; Berger Christoph investigator.; Berishvili Ekaterine investigator.; Binet Isabelle investigator.; Bochud Pierre‐Yves investigator.; Branca Sanda investigator.; Bucher Heiner investigator.; Carrel Thierry investigator.; Catana Emmanuelle investigator.; Chalandon Yves investigator.; De Geest Sabina investigator.; De Rougemont Olivier investigator.; De Seigneux Sophie investigator.; Dickenmann Michael investigator.; Dreifuss Joëlle Lynn investigator.; Duchosal Michel investigator.; Fehr Thomas investigator.; Ferrari‐Lacraz Sylvie investigator.; Franscini Nicola investigator.; Garzoni Christian investigator.; Soccal Paola Gasche investigator.; Gaudet Christophe investigator.; Golshayan Déla investigator.; Goossens Nicolas investigator.; Hadaya Karine investigator.; Halter Jörg investigator.; Heim Dominik investigator.; Hess Christoph investigator.; Hillinger Sven investigator.; Hirsch Hans investigator.; Hirt Patricia investigator.; Hofbauer Günther investigator.; Huynh‐Do Uyen investigator.; Immer Franz investigator.; Koller Michael investigator.; Laager Mirjam investigator.; Laesser Bettina investigator.; Lehmann Roger investigator.; Leichtle Alexander investigator.; Lovis Christian investigator.; Manuel Oriol investigator.; Marti Hans‐Peter investigator.; Martin Pierre Yves investigator.; Martinelli Michele investigator.; McLin Valérie investigator.; Mellac Katell investigator.; Merçay Aurélia investigator.; Mettler Karin investigator.; Mueller Nicolas investigator.; Müller Antonia investigator.; Müller‐Arndt Ulrike investigator.; Müllhaupt Beat investigator.; Nägeli Mirjam investigator.; Oldani Graziano investigator.; Pascual Manuel investigator.; Posfay‐Barbe Klara investigator.; Rick Juliane investigator.; Rosselet Anne investigator.; Rossi Simona investigator.; Rothlin Silvia investigator.; Ruschitzka Frank investigator.; Schachtner Thomas investigator.; Schanz Urs investigator.; Schaub Stefan investigator.; Schnyder Aurelia investigator.; Schuurmans Macé investigator.; Sengstag Thierry investigator.; Simonetta Federico investigator.; Stampf Susanne investigator.; Steiger Jürg investigator.; Stirniman Guido investigator.; Stürzinger Ueli investigator.; Van Delden Christian investigator.; Venetz Jean‐Pierre investigator.; Villard Jean investigator.; Vionnet Julien investigator.; Wick Madeleine investigator.; Wilhlem Markus investigator.; Yerly Patrick investigator.;
• Is Part Of: Alimentary pharmacology & therapeutics. Volume 56:Issue 7(2022)
• Page Start: 1194
• Page End: 1204
• Publication Date: 2022-08-18
• Subjects: cardiovascular disease -- dyslipidemia -- solid organ transplantation -- survival; Digestive organs -- Diseases -- Treatment -- Periodicals; Digestive organs -- Effect of drugs on -- Periodicals; Gastrointestinal system -- Diseases -- Treatment -- Periodicals; Gastrointestinal system -- Effect of drugs on -- Periodicals; 615.73
• DOI: 10.1111/apt.17192
• Languages: English
• ISSNs: 0269-2813

Abstract

Summary: Background: There is limited information on the effects of statins on the outcomes of liver transplantation (LT), regarding either their use by LT recipients or donors. Aim: To analyse the association between statin exposure and recipient and graft survival. Methods: We included adult LT recipients with deceased donors in a nationwide prospective database study. Using a multistate modelling approach, we examined the effect of statins on the transition hazard between LT, biliary and vascular complications and death, allowing for recurring events. The observation time was 3 years. Results: We included 998 (696 male, 70%, mean age 54.46 ± 11.14 years) LT recipients. 14% of donors and 19% of recipients were exposed to statins during the study period. During follow‐up, 141 patients died; there were 40 re‐LT and 363 complications, with 66 patients having two or more complications. Treatment with statins in the recipient was modelled as a concurrent covariate and associated with lower mortality after LT (HR = 0.35; 95% CI 0.12–0.98; p = 0.047), as well as a significant reduction of re‐LT ( p = 0.004). However, it was not associated with lower incidence of complications (HR = 1.25; 95% CI = 0.85–1.83; p = 0.266). Moreover, in patients developing complications, statin use was significantly associated with decreased mortality (HR = 0.10; 95% CI = 0.01–0.81; p = 0.030), and reduced recurrence of complications (HR = 0.43; 95% CI = 0.20–0.93; p = 0.032). Conclusions: Statin use by LT recipients may confer a survival advantage. Statin administration should be encouraged in LT recipients when clinically indicated. Abstract : Statin use after liver transplantation is associated with improved survival.