PH-Dependent fluorescence of [La(OH)2]+[ARS]− hybrid nanoparticles for intracellular pH-sensing. Issue 67 (2nd August 2022)

• Record Type: Journal Article
• Authors: Sabljo, Kristina; Napp, Joanna; Alves, Frauke; Feldmann, Claus
• Is Part Of: Chemical communications. Volume 58:Issue 67(2022)
• Page Start: 9417
• Page End: 9420
• Publication Date: 2022-08-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc01507b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : [La(OH)2 ] + [ARS] − inorganic–organic hybrid nanoparticles (ARS: alizarin red S) exhibit pH-dependent absorption and pH-dependent emission, allowing to monitor nanoparticle internalization in cells and the intracellular pH. Abstract : Saline inorganic–organic hybrid nanoparticles (IOH-NPs) [La(OH)2 ] + [ARS] − (ARS: alizarin red S) are prepared in water as a new compound (particle size: 47 ± 7 nm, ARS load: 65 wt%). The IOH-NPs not only show a pH-dependent absorption colour but also a pH-dependent fluorescence with green emission at pH 5.0–9.0 and red emission at pH < 4.5. According to first in vitro studies, the pH-dependend fluorescence can be used to monitor nanoparticle internalization in cells as well as the respective intracellular pH.