Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture. Issue 67 (2nd August 2022)
- Record Type:
- Journal Article
- Title:
- Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture. Issue 67 (2nd August 2022)
- Main Title:
- Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture
- Authors:
- Guy, Collette S.
Tomás, Ruben M. F.
Tang, Qiao
Gibson, Matthew I.
Fullam, Elizabeth - Abstract:
- Abstract : Antitubercular 'clickable' diboronic acid agents are directly incorporated into the mycobacterial cell envelope through glycan-targeting. Abstract : Dimeric boronic acids kill Mycobacterium tuberculosis ( Mtb ) by targeting mycobacterial specific extracellular glycans, removing the requirement for a therapeutic agent to permeate the complex cell envelope. Here we report the successful development and use of new 'clickable' boronic acid probes as a powerful method to enable the direct detection and visualisation of this unique class of cell-surface targeting antitubercular agents.
- Is Part Of:
- Chemical communications. Volume 58:Issue 67(2022)
- Journal:
- Chemical communications
- Issue:
- Volume 58:Issue 67(2022)
- Issue Display:
- Volume 58, Issue 67 (2022)
- Year:
- 2022
- Volume:
- 58
- Issue:
- 67
- Issue Sort Value:
- 2022-0058-0067-0000
- Page Start:
- 9361
- Page End:
- 9364
- Publication Date:
- 2022-08-02
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d2cc02407a ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 23415.xml