Correlation between adipocyte fatty acid binding protein and glucose dysregulation is closely associated with obesity and metabolic syndrome: A cohort of Han Chinese population from Yunnan plateau. Issue 4 (1st July 2022)

• Record Type: Journal Article
• Authors: Huang, Juan; Chen, Guo; Zhang, Qiao; Wang, Yanjiao; Meng, Qiong; Xu, Fang; Zhang, Xuehui; Zou, Wei; Mi, Fei; Yin, Jianzhong
• Is Part Of: Lipids. Volume 57:Issue 4/5(2022)
• Page Start: 257
• Page End: 264
• Publication Date: 2022-07-01
• Subjects: adipocyte fatty acid‐binding protein -- glucose dysregulation -- obesity -- plateau; Lipids -- Periodicals; Lipids -- Periodicals; Lipiden; Lipides -- Périodiques; 547.77
• DOI: 10.1002/lipd.12353
• Languages: English
• ISSNs: 0024-4201

Abstract

Abstract: The present study investigated the correlation of plasma A‐FABP with glucose dysregulation under different body mass index (BMI) and metabolic states in a Han Chinese population from Yunnan plateau. We cross‐sectionally analyzed data from the China Multi Ethnic Cohort, Yunnan province. Participants were divided into two groups. Group A contained 297 obese individuals with metabolic syndrome (MetS). Group B contained 326 age‐, sex‐, and region‐matched normal BMI subjects without MetS. Glucose dysregulation was defined as elevated fasting plasma glucose (FPG) (FPG ≥ 5.6 mmol/L or current use of oral hypoglycemic agents or insulin). Circulating A‐FABP were assayed by ELISA method. Binary and multiple regression analyses were preformed to evaluate the correlation between A‐FABP and glucose dysregulation. Plasma A‐FABP level was significantly higher in group A compared with group B ( p < 0.001). Plasma A‐FABP level correlated positively with elevated FPG in group A ( r = 0.120, p = 0.039), but negatively with elevated FPG in group B ( r = −0.115, p = 0.039). Multiple logistic regression analysis revealed that A‐FABP was an independent predictor for elevated FPG in group A ( β, 0.028; 95% CI, 1.001–1.056; p < 0.05), but not in group B ( β, −0.008; 95% CI, 0.882–1.117; p > 0.05). In this study, A‐FABP was an independent risk factor for glucose dysregulation in obese individuals with MetS living in the Yunnan plateau, but not for those without obesity and MetS.