Schwann Cells in Peripheral Cancers: Bystanders or Promoters?. Issue 9 (3rd June 2022)

• Record Type: Journal Article
• Authors: Yurteri, Ümmügülsüm; Çifcibaşı, Kaan; Friess, Helmut; Ceyhan, Güralp O.; Istvanffy, Rouzanna; Demir, Ihsan Ekin
• Other Names: Amit Moran guestEditor.
• Is Part Of: Advanced biology. Volume 6:Issue 9(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-06-03
• Subjects: cancer -- immune cells pancreatic cancer -- Schwann cells -- tissue repair; Molecular biology -- Periodicals; Systems biology -- Periodicals; Biological systems -- Periodicals; Biotechnology -- Periodicals; Bioengineering -- Periodicals; Biomedical engineering -- Periodicals; 660.6
• DOI: 10.1002/adbi.202200033
• Languages: English
• ISSNs: 2701-0198

Abstract

Abstract: The tumor microenvironment is subject to intense investigation in terms of its influence on tumorigenesis. Despite the fact that Schwann cells are cancer cells' early interaction partners, investigations on tumor progression and the molecular drivers of carcinogenesis do not place enough emphasis on them. Recent studies have shown that malignant cells and nerves interact on several levels during early carcinogenesis. For instance, the emergence of nerves in cancer, known as cancer neo‐neurogenesis, is one important mechanism that contributes to cancer progression. Recent studies on Schwann cells brought the investigation of tumor–nerve interactions to a whole new level. Schwann cells make up the majority of glial cells in the peripheral nervous system, are outstandingly plastic cells, and serve a variety of roles in most organs. All these properties make Schwann cells excellent potential targets for tumor cells to exploit and turn them into promoters of carcinogenesis. In the present review, the distinctive features of Schwann cell–tumor cell interactions and the implications of this interaction on the tumor microenvironment are outlined. Further, this study points out the neglected aspects of Schwann cells in the tumor microenvironment and provides a potential new avenue for future research. Abstract : Schwann cells have emerged in recent years as key actors in cancer evolution. They can activate growth‐, invasion‐ and metastasis‐related molecular programs in cancer cells. In turn, cancer cells exploit the regeneration‐enabling capacity of Schwann cells, which co‐opt immune and other stromal cells in the progression of cancer.