Anesthetic considerations in Dravet syndrome. Issue 10 (20th July 2022)

• Record Type: Journal Article
• Authors: Macdonald‐Laurs, Emma; Corlette, Sebastian; Davidson, Andrew; Howell, Katherine B.
• Is Part Of: Paediatric anaesthesia. Volume 32:Issue 10(2022)
• Page Start: 1166
• Page End: 1168
• Publication Date: 2022-07-20
• Subjects: adverse events -- complications -- drugs -- epilepsy -- local anesthetics -- neurological disease; Pediatric anesthesia -- Periodicals; 617.96798
• DOI: 10.1111/pan.14525
• Languages: English
• ISSNs: 1155-5645

Abstract

Abstract: We describe a two‐year‐old boy with Dravet syndrome, a severe genetic epilepsy, who developed a generalized tonic–clonic seizure immediately following an intravenous bolus of lidocaine given for propofol pain amelioration during induction of anesthesia for emergency gastroscopy. Although lidocaine has not specifically been reported as potentiating seizures in Dravet syndrome, it is well‐established that sodium channel blockers can worsen seizures in this population.