Dual Biosignal‐Functional Injectable Microspheres for Remodeling Osteogenic Microenvironment (Small 36/2022). Issue 36 (8th September 2022)

• Record Type: Journal Article
• Authors: Sun, Yang; Zhou, Qianrong; Du, Yawei; Sun, Jian; Bi, Wei; Liu, Wenjuan; Li, Ruixue; Wu, Xingwen; Yang, Fei; Song, Liang; Li, Ni; Cui, Wenguo; Yu, Youcheng
• Is Part Of: Small. Volume 18:Issue 36(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-08
• Subjects: dual signals -- IL‐4/Ls/PLLA microspheres -- microenvironment -- osteogenesis -- regenerative medicine; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202270190
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Bone Defect Treatment Inspired by the concept of macrophage reprogramming, Wenguo Cui, Youcheng Yu, and co‐workers construct immuno‐engineering porous microspheres (IL‐4/loaded liposomes (Ls)/poly (l‐lactic acid) (PLLA)) to realize bone repair through the "physical" porous structure and "molecular" IL‐4 chemokines dual signal regulation. The immuno‐reprogramming IL‐4/Ls/PLLA microspheres achieve the precise immuno‐reprogramming of macrophages by driving the activation of the signaling pathways. This immune reengineering strategy paves the way for clinical bone defect treatment.