Evolution of SIVmac239 following serial passaging in humanized mice. Issue 5 (28th August 2022)

• Record Type: Journal Article
• Authors: Curlin, James Z.; Schmitt, Kimberly; Remling‐Mulder, Leila; Morrison, Jared; Baczenas, John J.; Tibbits, Corina Valencia; Goff, Kelly; O'Connor, Shelby; Stenglein, Mark; Marx, Preston; Akkina, Ramesh
• Is Part Of: Journal of medical primatology. Volume 51:Issue 5(2022)
• Page Start: 284
• Page End: 287
• Publication Date: 2022-08-28
• Subjects: cross‐species SIV transmission -- HIV evolution surrogate model -- humanized mice -- rhesus macaques -- SIVmac239 cross‐species transmission -- SIVmac239 evolution -- SIVmac239 infection of humanized mice; Primates -- Periodicals; Primates -- Diseases -- Periodicals; Medicine, Experimental -- Periodicals; 616.02738
• DOI: 10.1111/jmp.12614
• Languages: English
• ISSNs: 0047-2565

Abstract

Abstract: Serial passage of SIVmac239 allows for greater understanding of the genetic changes necessary for cross‐species transmission of primate lentiviruses into humans. Using humanized mice, we show that adaptive mutations continue to accumulate in SIVmac239 during four serial passages, with persistent CD4 + T cell decline and increases in plasma viral loads.