Organ‐on‐a‐Chip: A Heart‐Breast Cancer‐on‐a‐Chip Platform for Disease Modeling and Monitoring of Cardiotoxicity Induced by Cancer Chemotherapy (Small 15/2021). Issue 15 (15th April 2021)

• Record Type: Journal Article
• Authors: Lee, Junmin; Mehrotra, Shreya; Zare‐Eelanjegh, Elaheh; Rodrigues, Raquel O.; Akbarinejad, Alireza; Ge, David; Amato, Luca; Kiaee, Kiavash; Fang, YongCong; Rosenkranz, Aliza; Keung, Wendy; Mandal, Biman B.; Li, Ronald A.; Zhang, Ting; Lee, HeaYeon; Dokmeci, Mehmet Remzi; Zhang, Yu Shrike; Khademhosseini, Ali; Shin, Su Ryon
• Is Part Of: Small. Volume 17:Issue 15(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-04-15
• Subjects: breast cancer -- cardiotoxicity -- electrochemical biosensors -- iPSC‐cardiac tissues -- organs‐on‐a‐chip; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202170070
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : In article number 2004258, Ali Khademhosseini, Su Ryon Shin, and co‐workers develop a model for investigating chemotherapy‐induced cardiotoxicity where induced pluripotent stem cell‐derived cardiac tissues are interacted with breast cancer tissues on a dual‐organ platform. Using electrochemical immuno‐aptasensors to monitor cell‐secreted multiple biomarkers, the proposed platform could be potentially suitable for early detection and prediction of cardiotoxicity in individual patients.