Antigens: Polymer Blend Particles with Defined Compositions for Targeting Antigen to Both Class I and II Antigen Presentation Pathways (Adv. Healthcare Mater. 5/2014). Issue 5 (5th May 2014)

• Record Type: Journal Article
• Authors: Tran, Kenny K.; Zhan, Xi; Shen, Hong
• Is Part Of: Advanced healthcare materials. Volume 3:Issue 5(2014:May)
• Page Start: 788
• Page End: 788
• Publication Date: 2014-05-05
• Subjects: adjuvants -- antigen presentation -- cross‐presentation -- blend polymers -- vaccines; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201470026
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : Blend nanoparticles, composed of a blend of polymers, serve as a vaccine delivery platform to deliver encapsulated antigens to dendritic cells. On page 690, blend particles control the delivery of antigens to both endolysosomal compartments and cytosolic space. Hong Shen and team show how, by controlling the polymer composition nanoparticles, protein antigens access to both MHC Class I and II antigen presentation pathways, engaging humoral, CD 4+ and CD 8+ T ‐ cell mediated immune responses.