Secretory Fluid‐Aggregated Janus Electrospun Short Fiber Scaffold for Wound Healing. Issue 36 (10th March 2022)

• Record Type: Journal Article
• Authors: Qian, Shutong; Wang, Juan; Liu, Zhimo; Mao, Jiayi; Zhao, Binfan; Mao, Xiyuan; Zhang, Liucheng; Cheng, Liying; Zhang, Yuguang; Sun, Xiaoming; Cui, Wenguo
• Is Part Of: Small. Volume 18:Issue 36(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-10
• Subjects: fluid‐aggregated scaffolds -- Janus structures -- short fibers -- wound exudates; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202200799
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: Exudate management is critical to improve chronic wound healing. Herein, inspired by a Janus‐structured lotus leaf with asymmetric wettability, a Janus electrospun short fiber scaffold is fabricated via electrospinning technologies and short fiber modeling. This scaffold is composed of hydrophilic 2D curcumin‐loaded electrospun fiber and hydrophobic 3D short fiber via layer‐by‐layer assembly and electrostatic interactions which can aggregate the wound exudate by pumping from the hydrophobic layer to the hydrophilic via multiple contact points between hydrophilic and hydrophobic fibers, and simultaneously trigger the cascade release of curcumin in the upper 2D electrospun fiber. The 3D short fiber with high porosity and hydrophobicity can quickly aggregate exudate within 30 s after compounding with hydrophilic 2D electrospun fiber via a spontaneous pump. In vitro experiments show that Janus electrospun short fiber has good biocompatibility, and the cascade release of curcumin can significantly promote the proliferation and migration of fibroblasts. In vivo experiments show that it can trigger cascade release of curcumin by aggregating wound exudate, so as to accelerate wound healing process and promote collagen deposition and vascularization. Hence, this unique biometric Janus scaffold provides an alternative for chronic wound healing. Abstract : A Janus electrospun short fiber scaffold is fabricated via a combination of electrospinning and short fiber modeling technologies. It can aggregate the wound exudate through pumping from the hydrophobic layer to the hydrophilic and simultaneously trigger the cascade release of curcumin in the upper membrane, thus promoting neovascularization and collagen deposition to accelerate wound healing.