Chronic immune thrombocytopenia in a child with X-linked agammaglobulinemia-an uncommon phenotype. (3rd October 2022)

• Record Type: Journal Article
• Authors: Yin, Jing; Ma, Jijun; Liu, Xiaoxue; Xia, Jingyue; Ai, Qi; Li, Chongwei
• Is Part Of: Platelets. Volume 33:Number 7(2022)
• Page Start: 1100
• Page End: 1103
• Publication Date: 2022-10-03
• Subjects: Autoimmunity immune -- thrombocytopenia -- X-linked agammaglobulinemia; Blood platelets -- Periodicals; Blood Platelets -- Periodicals; 615.39
• DOI: 10.1080/09537104.2022.2053090
• Languages: English
• ISSNs: 0953-7104

Abstract

Abstract: Autoimmune disorders are common in patients with primary immunodeficiency diseases (PIDs). However, the prevalence of autoimmunity is low in patients with X-linked agammaglobulinemia (XLA), mostly due to the absence of antibodies. Chronic or persistent immune thrombocytopenia (ITP), which is usually considered an antibody-mediated disease, is uncommon in patients with XLA. In this study, we detailly described a surprising autoimmune phenomenon, chronic ITP, in a small boy diagnosed with XLA. This is an interesting phenotype found in XLA, and it is helpful to understand the immune pathogenesis of autoimmunity in patients with XLA.