Fetal brain biometry in isolated mega cisterna magna: MRI and US study. (2nd November 2022)

• Record Type: Journal Article
• Authors: Gafner, Michal; Yagel, Itai; Fried, Shalev; Ezra, Osnat; Bar-Yosef, Omer; Katorza, Eldad
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 35:Number 21(2022)
• Page Start: 4199
• Page End: 4207
• Publication Date: 2022-11-02
• Subjects: Cisterna magna; -- fetus; -- ultrasonography; -- magnetic resonance imaging; -- central nervous system; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2020.1849094
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective: To characterize the biometric parameters in ultrasound and brain MRI of fetuses with isolated mega cisterna magna (MCM). Methods: Cross-sectional historical cohort study conducted at a single tertiary medical center between 2011 and 2018. All fetuses underwent US and brain MRI scans. Matching analysis was performed according to gender and gestational age. Results: The study included a total of 103 fetuses; 44 fetuses with isolated MCM in the study group, and a control group of 59 fetuses with normal CNS. The study group had larger biparietal diameter (BPD) (86 vs. 79.8 mm, p = .001) and head circumference (HC) (318 vs. 292 mm, p < .001) on ultrasound. On MRI, study group had larger occipitofrontal diameter (OFD) (99 vs. 92 mm, p < .001) and BPD (77 vs. 72 mm, p < .001). Male fetuses' prevalence was higher in the study group (77.3% vs. 47.5%). After matching 20 fetuses from each group, the study group had larger HC (310.1 versus 300.7 mm, p = .029) and OFD (113.4 versus 108.3 mm, p = .009) on ultrasound, and larger OFD (97.4 versus 94.6, p = .013) on brain MRI. Conclusions: Isolated MCM may be related to other large fetal CNS biometric measurements in both ultrasound and MRI and might be influenced by fetal gender.