Nutraceuticals and polycystic ovary syndrome: a systematic review of the literature. (3rd August 2022)

• Record Type: Journal Article
• Authors: Menichini, Daniela; Ughetti, Claudia; Monari, Francesca; Di Vinci, Pier Luigi; Neri, Isabella; Facchinetti, Fabio
• Is Part Of: Gynecological endocrinology. Volume 38:Number 8(2022)
• Page Start: 623
• Page End: 631
• Publication Date: 2022-08-03
• Subjects: Nutraceuticals -- PCOS -- inositol -- vitamin D -- probiotics -- vitamin E; 营养保健品 -- 多囊卵巢综合征 -- 肌醇 -- 维生素D -- 益生菌 -- 维生素E; Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.1080/09513590.2022.2089106
• Languages: English
• ISSNs: 0951-3590

Abstract

Abstract: Background This study proposes a review of nutraceuticals used in the treatment of typical symptoms of Polycystic Ovary Syndrome (PCOS). The aim is to provide a classification of the most widely used nutraceutical supplements identifying the most effective nutraceuticals on glucose and insulin metabolism, the androgenic hormone profile, fertility, ovulatory capacity, inflammation, and oxidative stress. Material and Methods We included randomized controlled trials on PCOS patients undergoing administration of nutraceuticals, in particular vitamin D, vitamin E, probiotics, and inositols. These administrations are variable in terms of dosage, single supplementation, or combined with other compounds, dosage, and duration of the intervention. Results The supplementation of inositols, at the physiologic ratio of 40: 1 of myo- and D-chiro-inositols, resulted to be the most effective in improving the glucose homeostasis and fertility, with a restoration of ovulatory capacity and menstrual regularity. Other nutraceuticals are particularly effective in reducing hyperandrogenism, with promising results demonstrated by the combinations of vitamin D and probiotics, vitamin E and coenzyme Q10, and the enrichment of inositol therapy with group B vitamins. An improvement in the inflammatory status and antioxidant capacity is obtained with the co-supplementation of probiotics and selenium or with vitamin E combined with omega 3. Conclusions Inositol supplementation is effective in the treatment of insulin resistance and fertility. Probiotics reduced hyperandrogenism, inflammatory and oxidative conditions, and resulted more effective when combined with selenium. Although these results proved to be satisfactory, further studies are needed with larger samples and a more homogeneous analysis of the outcomes.