Hyperglycemia in nondiabetic adult trauma patients is associated with worse outcomes than diabetic patients: An analysis of 95, 764 patients. Issue 3 (1st September 2022)

• Record Type: Journal Article
• Authors: Fakhry, Samir M.; Morse, Jennifer L.; Wilson, Nina Y.; Waswick, William A.; Garland, Jeneva M.; Chipko, John M.; Wyse, Ransom J.; Elkbuli, Adel; Dunne, James; Litow, Kyle J.; Duane, Therèse M.; Fisher, Chris; Shillinglaw, William C.; Banton, Kaysie L.; Biswas, Saptarshi; Plurad, David; Watts, Dorraine D.
• Is Part Of: Journal of trauma and acute care surgery. Volume 93:Issue 3(2022)
• Page Start: 316
• Page End: 322
• Publication Date: 2022-09-01
• Subjects: Hyperglycemia -- wounds and injuries -- outcomes -- mortality -- diabetes mellitus; Surgical intensive care -- Periodicals; Surgical emergencies -- Periodicals; Wounds and injuries -- Surgery -- Periodicals; 617.026
• DOI: 10.1097/TA.0000000000003576
• Languages: English
• ISSNs: 2163-0755

Abstract

Abstract : Hyperglycemia is associated with increased odds of mortality in both diabetic and non-diabetic trauma patients. Hyperglycemia during hospitalization in non-diabetics was associated with the worst outcomes and represents an opportunity for intervention in this high-risk group. Abstract : BACKGROUND: The adverse impact of acute hyperglycemia is well documented but its specific effects on nondiabetic trauma patients are unclear. The purpose of this study was to analyze the differential impact of hyperglycemia on outcomes between diabetic and nondiabetic trauma inpatients. METHODS: Adults admitted 2018 to 2019 to 46 Level I/II trauma centers with two or more blood glucose tests were analyzed. Diabetes status was determined from International Classification of Diseases—10th Rev.—Clinical Modification, trauma registry, and/or hemoglobin A1c greater than 6.5. Patients with and without one or more hyperglycemic result >180 mg/dL were compared. Logistic regression examined the effects of hyperglycemia and diabetes on outcomes, adjusting for age, sex, Injury Severity Score, and body mass index. RESULTS: There were 95, 764 patients: 54% male; mean age, 61 years; mean Injury Severity Score, 10; diabetic, 21%. Patients with hyperglycemia had higher mortality and worse outcomes compared with those without hyperglycemia. Nondiabetic hyperglycemic patients had the highest odds of mortality (diabetic: adjusted odds ratio, 3.11; 95% confidence interval, 2.8–3.5; nondiabetics: adjusted odds ratio, 7.5; 95% confidence interval, 6.8–8.4). Hyperglycemic nondiabetics experienced worse outcomes on every measure when compared with nonhyperglycemic nondiabetics, with higher rates of sepsis (1.1 vs. 0.1%, p < 0.001), more SSIs (1.0 vs. 0.1%, p < 0.001), longer mean hospital length of stay (11.4 vs. 5.0, p < 0.001), longer mean intensive care unit length of stay (8.5 vs. 4.0, p < 0.001), higher rates of intensive care unit use (68.6% vs. 35.1), and more ventilator use (42.4% vs. 7.3%). CONCLUSION: Hyperglycemia is associated with increased odds of mortality in both diabetic and nondiabetic patients. Hyperglycemia during hospitalization in nondiabetics was associated with the worst outcomes and represents a potential opportunity for intervention in this high-risk group. LEVEL OF EVIDENCE: Therapeutic/care management; Level III. Abstract :