Gender disparities in lung cancer survival from an enriched Florida population-based cancer registry. (December 2020)

• Record Type: Journal Article
• Authors: Elkbuli, Adel; Byrne, Margaret M.; Zhao, Wei; Sutherland, Mason; McKenney, Mark; Godinez, Yeissen; Dave, Devina J.; Bouzoubaa, Layla; Koru-Sengul, Tulay
• Is Part Of: Annals of medicine and surgery. Volume 60(2021)
• Page Start: 680
• Page End: 685
• Publication Date: 2020-12
• Subjects: Lung cancer survival -- Health inequalities -- Gender disparity -- Socioeconomic status -- Healthcare access; Surgery -- Periodicals; Medicine -- Periodicals; General Surgery -- Periodicals; Education, Medical -- Periodicals; Periodicals; 617
• DOI: 10.1016/j.amsu.2020.11.081
• Languages: English
• ISSNs: 2049-0801

Abstract

Abstract: Background: Previous studies have revealed gender disparities in lung cancer survivorship, but comprehensive inclusion of clinical/individual variables which affect outcomes is underreported. We utilized the Florida Data Cancer System (FCDS) to examine associations between gender and lung cancer survivorship while controlling for prognostic variables on a large population-based scale. Methods: A retrospective cohort analysis utilizing the FCDS, linked to Florida Agency for Health Care Administration and US Census Bureau tracts for patients diagnosed with primary lung cancer (n = 165, 465) from 1996 to 2007. Primary outcome measures included median survival time and mortality. Multivariable Cox regression models, independent sample T-tests, and descriptive statistics were utilized with significance defined as p < 0.05. Results: 165, 465 cases were analyzed revealing 44.3% females and 55.7% males. The majority of patients were white/Caucasian, males, middle-high socioeconomic status, lived in urban areas, and geriatric age. Females had longer median survival compared to males (9.6 vs 7.1 months). Multivariable analyses showed that women had better survival after controlling for sociodemographic, clinical, and comorbidity covariates. Males had higher risk of mortality than females (aHR = 1.17, 95%CI 1.14–1.19, p < 0.01). Conclusions: Individuals of higher socioeconomic status experienced greater survivorship compared to those of lower socioeconomic status. Women experienced significantly better survival for lung cancer at multiple time frames after controlling for covariates compared to men. Interventions aimed at public education and access to high-quality healthcare are needed to ameliorate socioeconomic and gender-based disparities in lung cancer survivorship. Future studies should investigate gender differences in lung cancer while incorporating individual socioeconomic status and treatment received. Highlights: Women have a significantly better survival for lung cancer at multiple time frames after controlling for covariates compared to men. The observations of our study shed light on a potential gender gap as well as economic disparities in overall lung cancer survivorship. This data accentuates the importance of focusing future preventative efforts on public education and the access to prompt healthcare in hopes of narrowing survival disparities in lung cancer.