Combination of platelet-rich plasma and stromal vascular fraction on the level of transforming growth factor-β in rat subjects experiencing deep dermal burn injury. (December 2020)

• Record Type: Journal Article
• Authors: Laidding, Sachraswaty Rachman; Josh, Fonny; Francisca, ; Faruk, Muhammad; Palissei, Andi Sinapati; Satria, Bayu; Warsinggih, ; Bukhari, Agussalim; Massi, Muh Nassrum; Islam, Andi Asadul
• Is Part Of: Annals of medicine and surgery. Volume 60(2021)
• Page Start: 737
• Page End: 742
• Publication Date: 2020-12
• Subjects: TGF-β -- Stromal vascular fraction -- Platelet-rich plasma -- Burn injury -- Experimental research; Surgery -- Periodicals; Medicine -- Periodicals; General Surgery -- Periodicals; Education, Medical -- Periodicals; Periodicals; 617
• DOI: 10.1016/j.amsu.2020.11.088
• Languages: English
• ISSNs: 2049-0801

Abstract

Abstract: Introduction: The combination of stromal vascular fraction (SVF) and platelet-rich plasma (PRP) is effective at increasing the concentration of growth factors including transforming growth factor-β (TGF-β). The increase in this growth factor is expected to accelerate the healing of burns. This study aims to determine the effect of giving a combination of SVFs and PRP on TGF-β levels in the healing process of deep dermal burns. Methods: This was an experimental study in 64 rats using a post-test control group design consisting of 1 group of SVFs and PRP combination injection treatment group, 1 group given a topical combination of SVFs and PRP, 1 group given Vaseline, and 1 control group. Results: There was a significant difference in TGF-β levels between the deep dermal burns group that was given a combination of SVFs and PRP injection and topical, the Vaseline group, and the control group with p-value <0.05. Conclusion: The combination of SVFs and PRP increases the level of TGF-β in the healing process of deep dermal burns. Highlights: The combination of SVFs and PRP is effective at increasing the concentration of growth factors. Administration of SVFs and PRP by injection was not better than topical at increasing the expression of TGF-β. The combination of SVFs and PRP increased the level of TGF-β in the healing process rats model.