PH-sensitive release of antioxidant Se-glycoconjugates through a flexible polymeric patch. (5th September 2022)

• Record Type: Journal Article
• Authors: Serpico, Luigia; Dello Iacono, Stefania; De Stefano, Luca; De Martino, Selene; Battisti, Mario; Dardano, Principia; Pedatella, Silvana; De Nisco, Mauro
• Is Part Of: European polymer journal. Volume 178(2022)
• Publication Date: 2022-09-05
• Subjects: Hydrogels -- Selenium glycoconjugates -- Antioxidant molecules -- Drug delivery -- Wound healing -- pH-sensitive release; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; Polymerization; Polymers; Periodicals; Electronic journals; 547.705
• DOI: 10.1016/j.eurpolymj.2022.111486
• Languages: English
• ISSNs: 0014-3057

Abstract

Graphical abstract: Highlights: Selenium glycoconjugates with antioxidant activity are synthesised and loaded into hydrogel-based patches. Poly(ethylene glycol) diacrylate and poly(hydroxyethyl methacrylate) are selected as polymeric films since they are biocompatible materials. A pH-sensitive release of the synthesised compounds is demonstrated. For both selenium glycoconjugates the diffusion mechanism appeared to be anomalous. The loaded system is potentially suitable for skin repair applications. Abstract: In this work, two novel selenium glycoconjugates are proposed as antioxidants to accelerate skin repair. These molecules, designed with more antioxidant sites and improved healing activity, are composed by a selenosugar covalently linked to a caffeic acid or a resveratrol residue. The selenium glycoconjugates have been synthesised and then loaded in a hydrogel flexible film, in order to obtain an active wound dressing. The chemical interaction between the hydrogel and the embedded selenium glycoconjugates can be modulated by the pH values, resulting in a pH-sensitive delivery system. In particular, the caffeic acid-containing compound is released at acute wounds' pH (7.4), while the resveratrol-containing conjugate is released at pH 9.6, typical of chronic wounds. The specific characteristics of the hydrogel and the antioxidant features of the selenium glycoconjugates, as well as the proven controlled release, candidate the designed system at wound care practices.