A tumor-targeting and polarity-specific near-infrared fluorescent probe for accurate cancer diagnosis in vivo. (October 2022)

• Record Type: Journal Article
• Authors: Wang, Wen-Xin; Wang, Zhi-Qing; Tan, Zhi-Ke; Guo, Ke-Yue; Mao, Guo-Jiang; Li, Yongfei; Li, Chun-Yan
• Is Part Of: Dyes and pigments. Volume 206(2022)
• Publication Date: 2022-10
• Subjects: Fluorescent probe -- Tumor-targeting -- Polarity-specific -- Near-infrared -- Accurate cancer diagnosis; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2022.110612
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: Although the cure rate of cancer is very low, the survival rate of patients can be improved if it is diagnosed early and treated in time. Polarity, as a significant parameter of tumor microenvironment, is bound up with the development of cancer. Unfortunately, there is currently no report about tumor-targeted and polarity-specific NIR fluorescent probe for accurate cancer diagnosis. Here, a polarity-specific near-infrared (NIR) fluorescent probe named CX-P based on coumarin-xanthene dye is reported. The probe has the advantages of long emission wavelength (>650 nm) and outstanding tumor targeting ability. CX-P is highly sensitive to polarity, and has a linear range from Δƒ = 0.284 (30% water) to Δƒ = 0.321 (100% water). Moreover, the probe can actively target cancer cells and display strong red fluorescence, while the fluorescence in normal cells is negligible. CX-P is also used to real-time monitor the polarity changes after the treatment of cancer cells with LPS, sucrose and taxol. Based on its NIR characteristics, CX-P is applied to real-time imaging of tumor-bearing mice and the significant tumor targeting ability is further confirmed. As far as we know, this is the first tumor-targeting and polarity-specific NIR fluorescent probe, which will offer a powerful means for accurate cancer diagnosis in the future. Graphical abstract: Image 1 Highlights: A novel polarity-specific fluorescent probe (CX-P) is successfully synthesized. CX-P shows NIR emission wavelength and outstanding tumor targeting ability. CX-P can monitor the cells polarity changes after treated with LPS, sucrose, taxol. .► CX-P is successfully applied to fluorescence imaging of tumor-bearing mice. This is the first tumor-targeting and polarity-specific NIR fluorescent probe.