Diagnostic capacity of sFlt-1/PlGF ratio in fetal growth restriction: A systematic review and meta-analysis. (September 2022)

• Record Type: Journal Article
• Authors: Chen, Wenjing; Wei, Qing; Liang, Qian; Song, Shurong; Li, Jia
• Is Part Of: Placenta. Volume 127(2022)
• Page Start: 37
• Page End: 42
• Publication Date: 2022-09
• Subjects: sFlt-1 -- PlGF -- Fetal growth restriction -- Pregnancy -- Meta-analysis; Placenta -- Periodicals; Reproduction -- Periodicals; Placenta -- Periodicals; Placenta -- Périodiques; Reproduction -- Périodiques; 612.63
• DOI: 10.1016/j.placenta.2022.07.020
• Languages: English
• ISSNs: 0143-4004

Abstract

Abstract: Introduction: We aimed to systemically investigate the diagnostic capacity of soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio in fetal growth restriction (FGR). Methods: We systematically searched the PubMed, MEDLINE, Cochrane Library, and EMBASE databases for relevant studies from inception to 15 May 2022. All potentially relevant studies were assessed and then pooled. Results: Eight studies with 339 patients and 5111 controls were included. A sFlt-1/PlGF ratio >33 was demonstrated a predictive value for FGR with a pooled sensitivity of [0.63, 95% confidence interval (CI) = 0.54–0.71], specificity of (0.84, 95% CI = 0.83–0.85), and area under the curve (AUC) of 0.8354. The pooled sensitivity, specificity, and AUC for the sFlt-1/PlGF ratio ≥85 group were 0.79 (95% CI = 0.66–0.89), 0.69 (95% CI = 0.65–0.74), and 0.8197, respectively. Discussion: These findings revealed that the sFlt-1/PlGF ratio could be a potential indicator in predicting FGR and FGR + PE. More studies are needed to support the conclusion. Highlights: Pregnant woman with FGR and PE may have higher sFlt-1/PlGF ratio. sFlt-1/PlGF ratio >33 showed strong predictive capacity in FGR. sFlt-1/PlGF ratio >33 and ≥ 85 demonstrated good predictive values for FGR + PE.