Effective enrichment and detection of bisphenol diglycidyl ether, novolac glycerol ether and their derivatives in canned food using a novel magnetic sulfonatocalix[6]arene covalent cross-linked polymer as the adsorbent. (15th January 2023) - Xie, Zenghui
Highlights: Magnetic sulfonatocalix[6]arene covalent cross-linked polymer (Fe3 O4 @pTMC-SC6A) prepared for sample pretreatment. Fe3 O4 @pTMC-SC6A could effectively enrichment epoxy derivatives. A simple and sensitive MSPE-UPLC-MS/MS method was established. The method used for the determination of epoxy derivatives in canned foods. Abstract: A core–shell magnetic sulfonatocalix[6]arene covalently cross-linked polymer was proposed as a magnetic adsorbent, combined with ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) for the enrichment and determination of epoxy derivatives in canned foods. The adsorbent has high density of host–guest recognition functional groups, abundant binding sites and suitable cavity size, showing good extraction performance for epoxy derivatives. Quantum chemical simulation calculations proved multiple interaction forces in the adsorption process. The extraction parameters were investigated. Under optimized experimental conditions, 13 kinds of target analytes showed low detection limits (0.0072–0.023 ng/g) and good precisions (RSDs of 0.8 %-9.4 %). This method has been successfully applied to the simultaneous determination of 13 kinds of epoxy derivatives in different food samples including canned beverage, fish, meat, and milk powder. Satisfactory recoveries (74.9 %–118 %) were obtained. The results showed the potential application prospects in the enrichment and detection of hazardous substances in food.