The prognostic effect of pretreatment 18F-FDG PET/CT metabolic parameters in locally advanced Esophageal Squamous Cell Carcinoma treated with definitive chemoradiotherapy. (August 2022)

• Record Type: Journal Article
• Authors: Sakin, Abdullah; Ozcelik, Mahsun; Sahin, Suleyman; Aydemir, Ozan; Aldemir, Mehmet Naci; Iliklerden, Umit Haluk; Kotan, Mehmet Cetin
• Is Part Of: Surgical oncology. Volume 43(2022)
• Publication Date: 2022-08
• Subjects: Metabolic tumor volume -- Tumor lesion glycolysis -- Esophageal cancer -- Chemoradiotherapy -- Squamous cell carcinoma; Cancer -- Surgery -- Periodicals; Neoplasms -- surgery -- Periodicals; Cancer -- Chirurgie -- Périodiques; Electronic journals; 616.994059
• DOI: 10.1016/j.suronc.2022.101809
• Languages: English
• ISSNs: 0960-7404

Abstract

Abstract: Introduction: In this study, we aimed to examine the relation between pre-treatment 18F-FDG PET/CT metabolic parameters [(including the maximum standard uptake value (SUVmax ), metabolic tumor volume (MTV), and tumor lesion glycolysis (TLG)] and treatment response and survival in locally-advanced Esophageal Squamous Cell Cancer (ESCC) treated with definitive chemoradiotherapy (dCRT). Methods: A total 76 patients with locally-advanced ESCC who received dCRT between June 2015 and December 2019 were included in this retrospective study. Patients were divided into two groups as complete response (CR) or non-complete response (Non-CR) according to response to treatment. AUC was obtained as 0.749 (p < 0.001) in the ROC curve drawn by MTV for the CR. The MTV value was ≤12 cm 3, with 72.1% sensitivity and 73.0% specificity. Results: Of the 76 patients, 38 (50%) were male and 38 (50%) were female. The median age was 62 (39–84) years. The treatment response in 35 (46%) patients was CR. MTV value was >12cm3 in 41(54%) patients. Median follow-up time was 14.5 months. In patients with MTV>12cm3, median progression-free survival(mPFS) and median overall survival(mOS) were 9 months and 11 months, respectively, whereas mPFS and OS could not be reached in those with MTV≤12 cm3 (p < 0.001 and p < 0.001, respectively). In patients with non-CR, mPFS and mOS were 8 months and 9 months, respectively, whereas mPFS and OS could not be reached in patients with CR (p < 0.001 and p < 0.001, respectively). In multivariate analysis, age (odds ratio [OR], 1.07), ECOG PS (OR, 11.1), and MTV (OR, 4.73) were found to be the factors affecting treatment response. Conclusion: In our study, treatment response and MTV were found to be the factors associated with survival in patients treated with dCRT, showing the pre-treatment MTV value as a predictor of treatment response. Highlights: 18F-FDG PET/CT is frequently used in cancer staging and follow-up. In this study, we aimed to examine the relation between pre-treatment 18F-FDG PET/CT metabolic parameters and treatment response and survival in locally-advanced Esophageal Squamous Cell Cancer (ESCC) treated with definitive chemoradiotherapy. The metabolic tumor volume (MTV) indicates the amount of aberrant FDG accumulation that is derived from a stable standardized uptake value (SUV) cut-off of 2.5 and a threshold of 42% of SUVmax . In the ROC curve using MTV, AUC was found as 0.749 for complete response. The MTV value was determined ≤12 cm3, with 72.1% sensitivity and 73.0% specificity. The present study showed that MTV can predict complete response in ESCC patients treated with dCRT, and therefore is associated with survival.