Clinical improvement of a toddler with COVID-19 focal cerebral arteriopathy possibly due to intra-arterial nimodipine. (September 2022)

• Record Type: Journal Article
• Authors: Avital, Dekel; Peretz, Shlomi; Perlow, Eliauh; Konen, Osnat; Inbar, Edna; Bulkowstein, Yarden; Nahum, Elhanan; Aharoni, Sharon; Vig, Lital Cohen; Nevo, Yoram; Auriel, Eitan; Straussberg, Rachel
• Is Part Of: European journal of paediatric neurology. Volume 40(2022)
• Page Start: 40
• Page End: 43
• Publication Date: 2022-09
• Subjects: Pediatric neurology -- Periodicals; Nervous System Diseases -- Periodicals; Child -- Periodicals; Infant -- Periodicals; Neurologie pédiatrique -- Périodiques; Pediatric neurology; Electronic journals; Periodicals; Electronic journals; 618.928
• DOI: 10.1016/j.ejpn.2022.07.007
• Languages: English
• ISSNs: 1090-3798

Abstract

Abstract: Pediatric stroke is considered an infrequent complication of COVID-19. Focal cerebral arteriopathy (FCA) is one of the most common causes of arterial ischemic stroke in a previously healthy child. The present report describes a toddler with FCA most likely induced by SARS-CoV-2 infection who showed significant clinical improvement that may be related to injection of intra-arterial nimodipine. To our knowledge, this is the first reported use of nimodipine in this setting. Highlights: This report describes a toddler with FCA most likely induced by SARS-CoV-2 infection. We describe significant clinical improvement possibly related to injection of intra-arterial nimodipine. To our knowledge, this is the first reported use of nimodipine in this setting. Efficacy and safety of intra-arterial nimodipine administration warrants further investigation.