Advances in Surface Plasmon Resonance-Based Biosensor Technologies for Cancer Cell Detection. (9th September 2022)

• Record Type: Journal Article
• Authors: Karki, Bhishma; Uniyal, Arun; Pal, Amrindra; Srivastava, Vivek
• Other Names: Chou Chau Yuan-Fong Academic Editor.
• Is Part Of: International journal of optics. Volume 2022(2022)
• Publication Date: 2022-09-09
• Subjects: Optics -- Periodicals; Optics; Periodicals; 535
• DOI: 10.1155/2022/1476254
• Languages: English
• ISSNs: 1687-9392

Abstract

Abstract : Efforts have been made to enhance the surface sensitivity of the conventional surface plasmon resonance biosensor. To improve the sensitivity, a unique two-dimensional heterostructure layer of titanium disilicide and black phosphorus layer has been deposited over the metal surface. The titanium disilicide (TiSi2 ) nanosheet is placed in between silver (Ag) and black phosphorus (BP) films in the Kretschmann arrangement. This biosensor executes better over a wide range of refractive index variations, including biological cell distribution in individual blood. It may become a fast method of detecting cancerous cells and the several variants of corona and other viruses that become pandemic. Using the finite element method-based simulation technique, the sensitivity obtained as 195.4 degree/RIU, 167.6 degree/RIU, 212.4 degree/RIU, 168.4 degree/RIU, 212.4 degree/RIU, 186.6 degree/RIU, 218.6 degree/RIU, 195.4 degree/RIU, 203.6 degree/RIU, 202.6 degree/RIU 203.6 degree/RIU, and 202.6 for basal (skin cancer), basal (normal cell), HeLa (cervical cancer), MCF-7 (breast cancer), HeLa (normal cell), Jurkat (blood cancer), Jurkat (normal cell), PCI-2 (adrenal gland cancer), PCI-2 (normal cell), MDA-MB-231 (breast cancer), MDA-MB-231 (normal cell), MCF-7 (breast cancer), and MCF-7 (normal cell), respectively, and other performance parameters such as detection accuracy, figure of merit, and full width and half maximum (FWHM) are also evaluated.