First experience of SARS‐CoV‐2 infections in solid organ transplant recipients in the Swiss Transplant Cohort Study. Issue 10 (9th June 2020)

• Record Type: Journal Article
• Authors: Tschopp, Jonathan; L'Huillier, Arnaud G.; Mombelli, Matteo; Mueller, Nicolas J.; Khanna, Nina; Garzoni, Christian; Meloni, Dario; Papadimitriou‐Olivgeris, Matthaios; Neofytos, Dionysios; Hirsch, Hans H.; Schuurmans, Macé M.; Müller, Thomas; Berney, Thierry; Steiger, Jürg; Pascual, Manuel; Manuel, Oriol; van Delden, Christian
• Other Names: Amico Patrizia investigator.; Aubert John‐David investigator.; Banz Vanessa investigator.; Beldi Guido investigator.; Benden Christian investigator.; Berger Christoph investigator.; Binet Isabelle investigator.; Bochud Pierre‐Yves investigator.; Branca Sanda investigator.; Bucher Heiner investigator.; Carell Thierry investigator.; Catana Emmanuelle investigator.; Chalandon Yves investigator.; de Geest Sabina investigator.; de Rougemont Olivier investigator.; Dickenmann Michael investigator.; Duchosal Michel investigator.; Elkrief Laure investigator.; Fehr Thomas investigator.; Ferrari‐Lacraz Sylvie investigator.; Garzoni Christian investigator.; Soccal Paola Gasche investigator.; Gaudet Christophe investigator.; Giostra Emiliano investigator.; Golshayan Déla investigator.; Hadaya Karine investigator.; Halter Jörg investigator.; Hauri Dimitri investigator.; Heim Dominik investigator.; Hess Christoph investigator.; Hillinger Sven investigator.; Hirsch Hans H investigator.; Hofbauer Günther investigator.; Huynh‐Do Uyen investigator.; Immer Franz investigator.; Klaghofer Richard investigator.; Koller Michael investigator.; Laesser Bettina investigator.; Laube Guido investigator.; Lehmann Roger investigator.; Lovis Christian investigator.; Majno Pietro investigator.; Manuel Oriol investigator.; Marti Hans‐Peter investigator.; Martin Pierre Yves investigator.; Martinelli Michele investigator.; Meylan Pascal investigator.; Mueller Nicolas J investigator.; Müller Antonia investigator.; Müller Thomas investigator.; Müllhaupt Beat investigator.; Pascual Manuel investigator.; Passweg Jakob investigator.; Posfay‐Barbe Klara investigator.; Rick Juliane investigator.; Roosnek Eddy investigator.; Rosselet Anne investigator.; Rothlin Silvia investigator.; Ruschitzka Frank investigator.; Schanz Urs investigator.; Schaub Stefan investigator.; Schnyder Aurelia investigator.; Schuurmans Macé investigator.; Seiler Christian investigator.; Sprachta Jan investigator.; Stampf Susanne investigator.; Steinack Carolin investigator.; Steiger Jürg investigator.; Stirnimann Guido investigator.; Toso Christian investigator.; Van Delden Christian investigator.; Venetz Jean‐Pierre investigator.; Villard Jean investigator.; Wick Madeleine investigator.; Wilhelm Markus investigator.; Yerly Patrick investigator.;
• Is Part Of: American journal of transplantation. Volume 20:Issue 10(2020)
• Page Start: 2876
• Page End: 2882
• Publication Date: 2020-06-09
• Subjects: clinical research/ practice -- complication: infectious -- infection and infectious agents -- infection and infectious agents ‐ viral -- infectious disease; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.16062
• Languages: English
• ISSNs: 1600-6135

Abstract

Abstract : Immunocompromised patients may be at increased risk for complications of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. However, comprehensive data of SARS‐CoV‐2 infection in solid organ transplant (SOT) recipients are still lacking. We performed a multicenter nationwide observational study within the Swiss Transplant Cohort Study (STCS) to describe the epidemiology, clinical presentation, treatment and outcomes of the first microbiologically documented SARS‐CoV‐2 infection among SOT recipients. Overall, 21 patients were included with a median age of 56 years (10 kidney, 5 liver, 1 pancreas, 1 lung, 1 heart and 3 combined transplantations). The most common presenting symptoms were fever (76%), dry cough (57%), nausea (33%), and diarrhea (33%). Ninety‐five percent and 24% of patients required hospital and ICU admission, respectively, and 19% were intubated. After a median of 33 days of follow‐up, 16 patients were discharged, 3 were still hospitalized and 2 patients died. These data suggest that clinical manifestations of SARS‐CoV‐2 infection in middle‐aged SOT recipients appear to be similar to the general population without an apparent higher rate of complications. These results need to be confirmed in larger cohorts. Abstract : This study describes the epidemiology, clinical presentation, treatment, and outcome of the first 21 solid organ transplant recipients infected with SARS‐CoV‐2 in the Swiss Transplant Cohort Study.