Basal progenitor cells bridge the development, malignant cancers, and multiple diseases of esophagus. Issue 5 (30th August 2017)

• Record Type: Journal Article
• Authors: Lin, Baoshun; Xie, Fuan; Xiao, Zhangwu; Hong, Xiaoqian; Tian, Liming; Liu, Kuancan
• Is Part Of: Journal of cellular physiology. Volume 233:Issue 5(2018:May)
• Page Start: 3855
• Page End: 3866
• Publication Date: 2017-08-30
• Subjects: Barrett esophagus -- basal progenitor cells -- eosinophilic esophagitis -- esophageal cancer -- gastroesophageal reflux disease; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.26136
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract : The esophagus is a pivotal organ originating from anterior foregut that links the mouth and stomach. Moreover, its development involves precise regulation of multiple signal molecules and signal transduction pathways. After abnormal regulation of these molecules in the basal cells of the esophagus occurs, multiple diseases, including esophageal atresia with or without tracheoesophageal fistula, Barrett esophagus, gastroesophageal reflux, and eosinophilic esophagitis, will take place as a result. Furthermore, expression changes of signal molecules or signal pathways in basal cells and the microenvironment around basal cells both can initiate the switch of malignant transformation. In this review, we highlight the molecular events underlying the transition of normal development to multiple esophageal diseases. Additionally, the animal models of esophageal development and related diseases, challenges, and strategies are extensively discussed. Abstract : After abnormal regulation of these molecules in the basal cells of the esophagus occurs, multiple diseases, including esophageal atresia with or without tracheoesophageal fistula, Barrett esophagus, gastroesophageal reflux, and eosinophilic esophagitis, will take place as a result. Furthermore, expression changes of signal molecules or signal pathways in basal cells and the microenvironment around basal cells both can initiate the switch of malignant transformation.