Characteristics of tendon derived stem cells according to different factors to induce the tendinopathy. Issue 8 (7th March 2018)

• Record Type: Journal Article
• Authors: Kim, Sun Jeog; Song, Da‐Hyun; Kim, Sang Jun
• Is Part Of: Journal of cellular physiology. Volume 233:Issue 8(2018:Aug.)
• Page Start: 6196
• Page End: 6206
• Publication Date: 2018-03-07
• Subjects: differentiation tendon -- proliferation -- stem cells -- tendinopathy; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.26475
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract : Tendon derived stem cells (TDSCs) have been used as a therapeutic agent and as a healing marker. However, there has been no study about the characteristics of TDSCs extracted from tendinopathic tendon tissues. The aim of this study was to find the different characteristics of TDSCs according to the factors to induce the tendinopathy. Five‐ and fifteen‐week old Sprague Dawley rats were used for this study and chemically‐induced and injury‐induced tendinopathy models were made depending on the age of the animal for different types of tendinopathy. TDSCs from chemically‐induced tendinopathy showed markedly low proliferation compared to those from age‐matched normal control and injury‐induced tendinopathy. In addition, TDSCs from chemically‐induced tendinopathy progressed to osteogenesis under an osteogenic differentiation environment more than those from other groups. In contrast, TDSCs from injury‐induced tendinopathy showed markedly high proliferation and high expression of type III collagen and α‐SMA compared to other groups. Adipogenic potentials in TDSCs from injury‐induced tendinopathy were also higher. These different characteristics might be helpful in the development new therapeutic agents for tendon regeneration according to different factors to induce the tendinopathy. Abstract : Five‐ and fifteen‐week old Sprague Dawley rats were used for this study and chemically‐induced and injury‐induced tendinopathy models were made. TDSCs from chemically‐induced tendinopathy showed markedly low proliferation and progressed to osteogenesis. TDSCs from injury‐induced tendinopathy showed markedly high proliferation and high expression of type III collagen and α‐SMA and progressed to adipogenesis.