A multi‐institutional phase 2 trial of stereotactic body radiotherapy in the treatment of bone metastases in pediatric and young adult patients with sarcoma. Issue 5 (10th November 2020)

• Record Type: Journal Article
• Authors: Elledge, Christen R.; Krasin, Matthew J.; Ladra, Matthew M.; Alcorn, Sara R.; Han, Peijin; Gibbs, Iris C.; Hiniker, Susan M.; Laack, Nadia N.; Terezakis, Stephanie A.
• Is Part Of: Cancer. Volume 127:Issue 5(2021)
• Page Start: 739
• Page End: 747
• Publication Date: 2020-11-10
• Subjects: neoplasm metastasis -- pediatrics -- radiotherapy -- sarcoma; Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.33306
• Languages: English
• ISSNs: 0008-543X

Abstract

Abstract : Background: Metastasectomy is standard of care for pediatric patients with metastatic sarcoma with limited disease. For patients with unresectable disease, stereotactic body radiotherapy (SBRT) may serve as an alternative. Herein, the authors report the results of a prospective, multi‐institutional phase 2 trial of SBRT in children and young adults with metastatic sarcoma. Methods: Patients aged >3 years and ≤40 years with unresected, osseous metastatic nonrhabdomyosarcoma sarcomas of soft tissue and bone were eligible. Patients received SBRT to a dose of 40 Gray (Gy) in 5 fractions. Local control (LC), progression‐free survival (PFS), and overall survival (OS) were calculated using the Kaplan‐Meier method. Results: Fourteen patients with a median age of 17 years (range, 4‐25 years) were treated to 37 distinct metastatic lesions. With a median follow‐up of 6.8 months (30.5 months in surviving patients), the Kaplan‐Meier patient‐specific and lesion‐specific LC rates at 6 months were 89% and 95%, respectively. The median PFS was 6 months and the median OS was 24 months. In a post hoc analysis, PFS (median, 9.3 months vs 3.7 months; log‐rank P = .03) and OS (median not reached vs 12.7 months; log‐rank P = .02) were improved when all known sites of metastatic disease were consolidated with SBRT compared with partial consolidation. SBRT was well tolerated, with 2 patients experiencing grade 3 toxicities. Conclusions: SBRT achieved high rates of LC in pediatric patients with inoperable metastatic nonrhabdomyosarcoma sarcomas of soft tissue and bone. These results suggest that the ability to achieve total consolidation of metastatic disease with SBRT is associated with improved PFS and OS. Abstract : A multi‐institutional phase 2 trial demonstrates that stereotactic body radiotherapy (SBRT) is safe and provides good local control for pediatric and young adult patients with metastatic nonrhabdomyosarcoma sarcomas. The ability to achieve total consolidation of metastatic disease with SBRT is associated with improved progression‐free survival and overall survival.