Radiological pseudoprogression post‐radiotherapy in a child with pineal germ cell tumour. Issue 7 (19th May 2020)

• Record Type: Journal Article
• Authors: Alves, Inês; Bodi, Istvan; Jarosz, Jozef; Mandeville, Henry; Zebian, Bassel; Carceller, Fernando
• Is Part Of: Pediatric blood & cancer. Volume 67:Issue 7(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-05-19
• Subjects: germ cell tumour -- germinoma -- intracranial -- paediatric -- pineal -- pseudoprogression -- teratoma; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.28407
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: Little is known about pseudoprogression in brain tumours other than gliomas. A 9‐year‐old male child with a pineal teratoma/germinoma underwent surgical resection followed by adjuvant chemo‐radiotherapy. The magnetic resonance imaging scan 4 months post‐radiotherapy showed a contrast‐enhancing lesion within the surgical cavity suspicious of recurrence. These radiological findings subsequently resolved without any specific intervention. The child continues in remission 2 years post‐treatment. This case illustrates the occurrence of pseudoprogression post‐radiotherapy in intracranial GCT and highlights an unmet need for greater implementation of functional imaging techniques in paediatric neuro‐oncology to avoid undue discontinuation of effective treatments or inappropriate enrolment in clinical trials.