NF‐kB signaling in cardiomyocytes is inhibited by sevoflurane and promoted by propofol. Issue 2 (15th January 2020)

• Record Type: Journal Article
• Authors: Oda‐Kawashima, Keiko; Sedukhina, Anna S.; Okamoto, Naoki; lytvyn, Mariya; Minagawa, Kimino; Iwata, Teppei; Kumai, Toshio; Sato, Eri; Inada, Eiichi; Yamaura, Ayako; Sakamoto, Miki; Roche‐Molina, Marta; Bernal, Juan A.; Sato, Ko
• Is Part Of: FEBS open bio. Volume 10:Issue 2(2020)
• Page Start: 259
• Page End: 267
• Publication Date: 2020-01-15
• Subjects: anesthesia -- bioinformatics -- myocardial remodeling -- NF‐kB -- propofol -- sevoflurane; Molecular biology -- Periodicals; Cytology -- Periodicals; Life sciences -- Periodicals; Biological Science Disciplines -- Periodicals; Molecular Biology -- Periodicals; Cell Biology -- Periodicals; Cytology; Life sciences; Molecular biology; Periodicals; 572.805
• DOI: 10.1002/2211-5463.12783
• Languages: English
• ISSNs: 2211-5463

Abstract

Abstract : Both inhalational and intravenous anesthetics affect myocardial remodeling, but the precise effect of each anesthetic on molecular signaling in myocardial remodeling is unknown. Here, we performed in silico analysis to investigate signaling alterations in cardiomyocytes induced by inhalational [sevoflurane (Sevo)] and intravenous [propofol (Prop)] anesthetics. Bioinformatics analysis revealed that nuclear factor‐kappa B (NF‐kB) signaling was inhibited by Sevo and promoted by Prop. Moreover, nuclear accumulation of p65 and transcription of NF‐kB‐regulated genes were suppressed in Sevo‐administered mice, suggesting that Sevo inhibits the NF‐kB signaling pathway. Our data demonstrate that NF‐kB signaling is inhibited by Sevo and promoted by Prop. As NF‐kB signaling plays an important role in myocardial remodeling, our results suggest that anesthetics may affect myocardial remodeling through NF‐kB. Abstract : The precise nature of the molecular alterations occurring after inhalation or intravenous anesthesia remains unclear. Here, in silico gene expression analysis of patient cardiomyocytes and a mouse animal model revealed that nuclear factor‐kappa B signaling is upregulated by sevoflurane and downregulated by propofol. Interestingly, this effect was observed only in the postanesthesia acute phase, not in the late phase.