Gut microbial clues to bipolar disorder: State‐of‐the‐art review of current findings and future directions. Issue 4 (12th August 2020)

• Record Type: Journal Article
• Authors: Lai, Jianbo; Jiang, Jiajun; Zhang, Peifen; Xi, Caixi; Wu, Lingling; Gao, Xingle; Zhang, Danhua; Du, Yanli; Li, Qunxiao; Diao, Xiangyuan; Lu, Shaojia; Wang, Zheng; Song, Xueqin; Hu, Shaohua
• Is Part Of: Clinical and translational medicine. Volume 10:Issue 4(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-08-12
• Subjects: gut microbiome -- bipolar disorder -- microbiome‐gut‐brain axis; Clinical medicine -- Periodicals; Medicine, Experimental -- Periodicals; Medical innovations -- Periodicals; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; 616.027
• DOI: 10.1002/ctm2.146
• Languages: English
• ISSNs: 2001-1326

Abstract

Abstract: Trillions of microorganisms inhabiting in the human gut play an essential role in maintaining physical and mental health. The connections between gut microbiome and neuropsychiatric diseases have been recently identified. The pathogenesis of bipolar disorder, a spectrum of diseases manifesting with mood and energy fluctuations, also seems to be involved in the bidirectional modulation of the microbiome‐gut‐brain (MGB) axis. In this review, we briefly introduce the concept of MGB axis, and then focus on the previous findings in human studies associated with bipolar disorder. These studies provided preliminary evidences on the gut microbial alterations in bipolar disorder. Limitations in these studies and future directions in this research field, such as fecal microbiome transplantation and microbiome‐targeted therapy, were discussed. A research framework linking gut microbiome to determinants and health‐related outcomes in BD was also proposed. Better characterizing and understanding of gut microbial biosignatures in bipolar patients contribute to clarify the etiology of this intractable disease and pave the new way for treatment innovation. Abstract : Previous studies have provided preliminary evidence that gut microbiome is closely linked to mental health in patients with bipolar disorder. Microbiome‐wide association studies help to illuminate the relationship between gut microorganisms and bipolar disorder. Manipulating the gut microbiome appears to be a promising strategy for treating bipolar disorder in the future.