Effect of local aromatase inhibition in endometriosis using a new chick embryo chorioallantoic membrane model. Issue 8 (14th June 2019)

• Record Type: Journal Article
• Authors: Pluchino, Nicola; Poppi, Giorgia; Yart, Lucile; Marci, Roberto; Wenger, Jean‐Marie; Tille, Jean‐Christophe; Cohen, Marie
• Is Part Of: Journal of cellular and molecular medicine. Volume 23:Issue 8(2019)
• Page Start: 5808
• Page End: 5812
• Publication Date: 2019-06-14
• Subjects: anastrozole -- chick embryo chorioallantoic membrane -- endometriosis; Cytology; Medicine; Molecular Biology; Cytologie -- Périodiques; Médecine -- Périodiques; Biologie moléculaire -- Périodiques; Cytology -- Periodicals; Medicine -- Periodicals; Molecular biology -- Periodicals; 611.01805
• DOI: 10.1111/jcmm.14372
• Languages: English
• ISSNs: 1582-1838

Abstract

Abstract: Endometriosis is an oestrogen‐dependent, inflammation‐driven gynaecologic disorder causing severe disability. Endometriosis implants are characterized by unbalanced local oestrogen metabolism leading to hyperoestrogenism and aromatase up‐regulation is one of main mechanism involved. Aromatase inhibitors such as letrozole or anastrozole use in young women are associated with severely side effects limiting their long‐term clinical use. An endometriosis‐targeted inhibition of local aromatase could be a viable alternative, although the role of the local inhibition of this enzyme is still unclear. Using a new chick embryo allantoic membrane (CAM) model incorporating xenografted human endometriosis cyst, we showed that topical treatment with anastrozole reduced lesion size, although oestrogens produced by CAM female embryo blunted this effect. Xenografted human endometriosis CAM is a new efficient model for the screening of new drugs targeting endometriosis tissue.