Save your gut save your age: The role of the microbiome in stem cell ageing. Issue 8 (17th June 2019)

• Record Type: Journal Article
• Authors: Tan, Yi; Wei, Zongke; Chen, Jiaoliu; An, Junli; Li, Manling; Zhou, Liuyun; Men, Yanhua; Zhao, Shan
• Is Part Of: Journal of cellular and molecular medicine. Volume 23:Issue 8(2019)
• Page Start: 4866
• Page End: 4875
• Publication Date: 2019-06-17
• Subjects: ageing -- gut permeability -- microbiome -- stem cell; Cytology; Medicine; Molecular Biology; Cytologie -- Périodiques; Médecine -- Périodiques; Biologie moléculaire -- Périodiques; Cytology -- Periodicals; Medicine -- Periodicals; Molecular biology -- Periodicals; 611.01805
• DOI: 10.1111/jcmm.14373
• Languages: English
• ISSNs: 1582-1838

Abstract

Abstract: The tremendous importance of microbiota in microbial homoeostasis, alterations in metabolism and both innate and adaptive immune systems has been well established. A growing body of evidence support that dysbiosis or compositional changes in gut microbiota is linked to the ageing of stem cells in terms of dysregulations of metabolism, aberrant activation of the immune system as well as promoting epigenetic instability of stem cell. In this concise review, we elucidate recent emerging topics on microbiotic alterations and underlying mechanisms in stem cell ageing. Abstract : The compositional changes in microbiome preserve the gut permeability and prevent aberrant activations of ageing related signalling pathways, ultimately thwarting the exhaustion of stem cell pool and postponing aging.