Immune Effect of T Lymphocytes Infiltrated by Tumors on Non-Small-Cell Lung Cancer. (10th September 2022)

• Record Type: Journal Article
• Authors: Sheng, Siyuan; Lu, Chuangang; Guo, Jianhui; Liu, Minjing; Wu, Yongdong
• Other Names: Cigerci İbrahim Hakkı Academic Editor.
• Is Part Of: Journal of oncology. Volume 2022(2022)
• Publication Date: 2022-09-10
• Subjects: Oncology -- Research -- Periodicals; Tumors -- Periodicals; Neoplasms; Oncology -- Research; Tumors; Periodicals; Periodicals; 616.994
• DOI: 10.1155/2022/4662874
• Languages: English
• ISSNs: 1687-8450

Abstract

Abstract : Lung cancer is increasing every year and it has high morbidity and mortality. Antitumor immunotherapy is a new method for the treatment of lung cancer. Currently, tumor immunotherapy mainly includes classical immunotherapy and immune-targeted therapy To explore the influence of tumor T-lymphocyte (T-cell) infiltration in non-small-cell lung cancer (NSCLC) patients, 100 NSCLC patients diagnosed and treated in Changde Second People's hospital were recruited. Patients were followed up for 3 years. The subjects were divided into a survival group (group S) and a death group (group D). The patient's pathological tissue sections were made, and the degree of T-cell infiltration was counted by H&E (Hematoxylin and eosin) staining. The infiltration degree was graded, and the positive rate of T-cell subsets was calculated by immunohistochemical staining. The 3-year positive rate was 48%, with 48 cases in group S and 52 cases in group D. The positive rate of H&E staining of group S was 100%, including 0 cases of grade 0, 5 cases of grade 1 (10.42%), 16 cases of grade 2 (33.33%), and 27 cases of grade 3 (56.25%). The positive rate of group D was 86.54%, including 4 cases of grade 0 (8.89%), 10 cases of grade 1 (22.22%), 25 cases of grade 2 (55.56%), and 6 cases of grade 3 (13.33%). The total number of T-cell infiltrates in group S was much higher than that in group D (P < 0.05 ). Immunohistochemical results showed that the mean positive rate of CD8 + T-cell infiltration was 72.1% in group S and 47.6% in group D, with a considerable difference (P < 0.05 ). No remarkable difference was found in CD4 + and CD25 + (P < 0.05 ). CD8 + + CD4 +, CD8 + /CD4 +, CD25 + /CD8 +, CD25 + /CD4 +, and CD25 + /(CD8 + + CD4 + ) positive rates were calculated, and the difference between group S and group D was substantial in CD8 + + CD4 + (P < 0.05 ). The results showed that T cells infiltrated by tumors had an immunosuppressive effect on tumor cells.