Suggesting 7, 8-dihydroxyflavone as a promising nutraceutical against CNS disorders. (September 2021)

• Record Type: Journal Article
• Authors: Paul, Rajib; Nath, Joyobrato; Paul, Satinath; Mazumder, Muhammed Khairujjaman; Phukan, Banashree Chetia; Roy, Rubina; Bhattacharya, Pallab; Borah, Anupom
• Is Part Of: Neurochemistry international. Volume 148(2021)
• Publication Date: 2021-09
• Subjects: BDNF-TrkB -- Neurodegenerative disorders -- Neuroprotection -- Anti-inflammatory; Neurochemistry -- Periodicals; Neurochemistry -- Periodicals; Neurochimie -- Périodiques; Neurochemistry; Periodicals; 612.804205
• DOI: 10.1016/j.neuint.2021.105068
• Languages: English
• ISSNs: 0197-0186

Abstract

Abstract: 7, 8-dihydroxyflavone (DHF), a naturally-occurring plant-based flavone, is a high-affinity tyrosine kinase receptor B (TrkB) agonist and a bioactive molecule of therapeutic interest for neuronal survival, differentiation, synaptic plasticity and neurogenesis. In the family of neurotrophic factors, this small BDNF-mimetic molecule has attracted considerable attention due to its oral bioavailability and ability to cross the blood-brain barrier. Recent evidences have shed light on the neuroprotective role of this pleiotropic flavone against several neurological disorders, including Alzheimer's disease, Parkinson's disease, cerebral ischemia, Huntington's disease, and other CNS disorders. DHF also elicits potent protective actions against toxins-induced insults to brain and neuronal cells. DHF shows promising anti-oxidant and anti-inflammatory properties in ameliorating the neurodegenerative processes affecting the CNS. This review provides an overview of the significant neuroprotective potentials of DHF and discusses how it exerts its multitudinous beneficial effects by modulating different pathways linked with the pathophysiology of CNS disorders, and thus proposes it to be a nutraceutical against a broad spectrum of neurological disorders. Graphical abstract: Image 1 Highlights: DHF confers neuroprotection in neurodegenerative disorders and toxins-induced neurotoxicity. Anti-inflammatory, antioxidant, and anti-apoptotic potentials of DHF confer neuroprotection. Symptomatic reprieve against CNS disorders is mediated by DHF. DHF can be regarded as a neuroprotective nutraceutical.