Autophagy-related microRNAs: Possible regulatory roles and therapeutic potential in and gastrointestinal cancers. (November 2020)

• Record Type: Journal Article
• Authors: Pourhanifeh, Mohammad Hossein; Vosough, Massoud; Mahjoubin-Tehran, Maryam; Hashemipour, Maryam; Nejati, Majid; Abbasi-Kolli, Mohammad; Sahebkar, Amirhossein; Mirzaei, Hamed
• Is Part Of: Pharmacological research. Volume 161(2020)
• Publication Date: 2020-11
• Subjects: 4E-BP1 4E (eIF4E)-binding protein 1 -- 5-FU 5-Fluorouracil -- AGR2 anterior gradient 2 -- AKAP1 A-Kinase Anchoring Protein 1 -- Akt Protein kinase B -- AKT1 AKT Serine/Threonine Kinase 1 -- ALCOCO2/ NDP52 calcium binding and coiled-coil domain 2 -- AMPK AMP-activated protein kinase -- ATG Autophagy-related genes -- Atg12 autophagy related 12 -- ATG12 autophagy through suppressing autophagy-related gene 12 -- ATG13 Autophagy-related protein 13 -- Atg14 Autophagy Related 14 -- ATG16L1 Autophagy related 16 like 1 -- ATG4D Autophagy Related 4D Cysteine Peptidase -- ATG5 Autophagy related 5 -- ATG7 autophagy related 7 -- ATG9A Autophagy Related 9A -- ATR ataxia-telangiectasia-mutated-and-Rad3-related kinase -- BAX BCL2 Associated X Protein -- BCL-2 B-cell lymphoma 2 -- BEZ235 Dactolisib -- Bif1 Bax-interacting factor 1 -- Bim Bcl-2-like protein 11 -- BTG1 BTG Anti-Proliferation Factor 1 -- CAB39 Calcium-binding protein 39 -- CEA carcinoembryonic antigen -- CHK1 checkpoint kinase 1 -- circRNAs circular RNAs -- CRC colorectal cancer -- CXCL12 C-X-C Motif Chemokine Ligand 12 -- CXCR4 C-X-C Motif Chemokine Receptor 4 -- DACT3 Dishevelled Binding Antagonist Of Beta Catenin 3 -- DGCR8 Drosha/DiGeorge syndrome chromosomal region 8 -- DNA Deoxyribonucleic acid -- DOX doxorubicin -- DRAM Damage-Regulated Autophagy Modulator -- DUSP10 Dual specificity phosphatase 10 -- EGFR Epidermal Growth Factor Receptor -- eIF4E eukaryotic translation initiation factor 4E -- EMT Epithelial-mesenchymal transition -- EMT epithelial–mesenchymal transition -- ER endoplasmic reticulum -- ERK extracellular signal-related kinase -- ESCC esophageal squamous-cell carcinoma -- EVA1A Eva-1 Homolog A -- EZH2 Enhancer of zeste homolog 2 -- FIP200 FAK family kinase-interacting protein of 200 kDa -- FOXO1 Forkhead box protein O1 -- G2/M Gap 2 phase/Mitosis -- GABARAPL1 GABA type A receptor associated protein like 1 -- GAS5 Growth arrest-specific 5 -- GI Gastrointestinal -- GLOBOCAN Global Cancer Observatory -- GRP78 Glucose-Regulated Protein, 78 kD -- HCC Hepatocellular carcinoma -- HDAC Histone deacetylase -- HDAC6 Histone deacetylase‑6 -- HIF-2α Hypoxia-inducible factor -- HMGB1 High-mobility group protein B1 -- HMGB2 High-mobility group protein B2 -- HPV Human Papillomaviru -- IGF-1R Insulin-like growth factor1 receptor -- JNK c-Jun N-terminal kinase -- JNK Jun amino-terminal kinases -- LC3 Microtubule-associated protein 1A/1B-light chain 3 -- LC3-I cytosolic form of LC3 -- LC3-II LC3-phosphatidylethanolamine conjugate -- LCC-DOX lipid-coated calcium carbonate nanoparticles -- LIB1 liver kinase B1 -- Linc-ROR Long Intergenic Non-Protein Coding RNA, Regulator Of Reprogramming -- lncRNAs long non-coding RNAs -- MALAT1 Metastasis Associated Lung Adenocarcinoma Transcript 1 -- MAP1S Microtubule-associated protein 1S -- MAP1S Microtubule Associated Protein 1S -- MAPK mitogen-activated protein kinases -- MCM3AP-AS1 MCM3AP antisense RNA 1 -- miRNAs micro RNAs -- MTMR3 myotubularin related protein 3 -- mTOR mammalian target of rapamycin -- mTOR1 mammalian target of rapamycin-1 -- mTORC1 mammalian target of rapamycin complex 1 -- NBR1 Neighbor Of BRCA1 Gene 1 -- NEAT1 Nuclear Enriched Abundant Transcript -- Nrf2 nuclear factor erythroid 2–related factor 2 -- OPTN Optineurin -- P38 Mitogen-Activated Protein Kinase 14 -- P62 Nucleoporin 62 -- PDAC pancreatic ductal adenocarcinoma cells -- PDX1 pancreatic duodenal homeobox 1 -- PGK1 phosphoglycerate kinase 1 -- PI3K Phosphoinositide 3-kinase -- PIK3C3 Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 -- piRNAs Piwi-interacting RNAs -- PKM1 Pyruvate kinase isozymes M1 -- PKm2 Pyruvate kinase isozymes M2 -- pri-miRNAs primary micro RNAs -- PTB1 polypyrimidine tract binding protein 1 -- PTBP1 Polypyrimidine tract-binding protein 1 -- PTEN Phosphatase and tensin homolog -- PVT1 Plasmacytoma Variant Translocation 1 -- RAB12 Ras-related protein Rab-12 -- Rab1B Ras-Related Protein Rab-1B -- Rab3IP RAB3A-interacting protein -- RAB5A Ras-related protein Rab-5A -- Rab7 Ras-Related Protein Rab-7a -- RanGTP GTP-binding nuclear protein Ran -- RHEB Ras homolog enriched in brain -- RICTOR Rapamycin-insensitive companion of mammalian target of rapamycin -- SAPK Stress-activated protein kinases -- SIRT1 sirtuin (silent mating type information regulation 2 homolog) 1 -- Smad2 Small mothers against decapentaplegic homolog 2 -- Smad4 Small mothers against decapentaplegic homolog 4 -- SNHG1 Small nucleolar rna host gene 1 -- SNHG14 Small Nucleolar RNA Host Gene 14 -- snoRNAs small nucleolar RNAs -- SQSTM1 Sequestosome 1 -- STAT3 Signal transducer and activator of transcription 3 -- STMN1 Stathmin 1 -- TFEB Transcription Factor EB -- TGF-β Transforming growth factor beta -- TNBC triple-negative breast cancer -- TNM TNM Classification of Malignant Tumors -- TP53INP1 tumor protein 53-m nuclear protein 1 -- ULK1 Unc-51 like autophagy activating kinase -- USP22 Ubiquitin Specific Peptidase 22 -- USP9X Ubiquitin Specific Peptidase 9 X-Linked -- UVRAG UV radiation resistance-associated gene -- UVRAG UV Radiation Resistance-Associated Gene -- VCP Valosin Containing Protein -- YEATS4 YEATS Domain Containing 4 -- YY1 Yin Yang 1 -- ZEB2 Zinc finger E-box-binding homeobox 2; MicroRNA -- Autophagy -- Gastrointestinal cancer -- Gastric cancer -- Liver cancer -- Pancreatic cancer -- Esophageal cancer -- Colorectal cancer -- Biomarker -- Epigenetic; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2020.105133
• Languages: English
• ISSNs: 1043-6618

Abstract

Abstract: Gastrointestinal (GI) cancers with a high incidence rate and adverse complications are associated with severe morbidity and mortality around the world. It is well recognized that early detection of the disease results in longer survival rate and better quality of life. Autophagy, an intracellular regulatory process, has been shown to play an essential role in the pathogenesis of various malignancies including GI cancers. MicroRNAs (miRNAs) are small non-coding RNAs that have regulatory functions in tumor cells and possess potential diagnostic values in early detection of cancers. It has been recently demonstrated that these molecules have modulatory effects on multiple steps of autophagy process occurring in GI malignancies. In this review, we aimed to highlight the role of autophagy-related microRNAs on GI cancer as potential targets for cancer therapy.