Nano indium oxide-catalyzed domino reaction for the synthesis of N-alkoxylated benzimidazoles. Issue 32 (6th August 2020)

• Record Type: Journal Article
• Authors: Samanta, Satyajit; Mahato, Sachinta; Chatterjee, Rana; Santra, Sougata; Zyryanov, Grigory V.; Majee, Adinath
• Is Part Of: Tetrahedron letters. Volume 61:Issue 32(2020)
• Publication Date: 2020-08-06
• Subjects: Nano indium oxide -- N-Alkoxylated benzimidazoles -- ortho-Phenylenediamine -- Formaldehyde -- Reusable catalyst; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2020.152177
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Nano-In2 O3 is found to be an efficient catalyst for three-component condensation. In2 O3 nanoparticles are recyclable without significant loss of catalytic activities. Applicable to gram-scale synthesis of N -alkoxylated benzimidazoles. Control experiments were done for mechanism studies. Abstract: A convenient method has been developed for the selective synthesis of N -alkoxylated benzimidazole derivatives by the cyclocondensation reaction of simple ortho -phenylenediamine, formaldehyde and alcohols in presence of indium oxide nanoparticles as catalyst. The alcohol acts as reactant as well as solvent in this reaction. No other solvents or additives have been used for this reaction. The catalyst can be reused several times without significant loss of catalytic activity. A probable reaction mechanism has been proposed based on some control experiments.