Lycopene - A pleiotropic neuroprotective nutraceutical: Deciphering its therapeutic potentials in broad spectrum neurological disorders. (November 2020)

• Record Type: Journal Article
• Authors: Paul, Rajib; Mazumder, Muhammed Khairujjaman; Nath, Joyobrato; Deb, Satarupa; Paul, Satinath; Bhattacharya, Pallab; Borah, Anupom
• Is Part Of: Neurochemistry international. Volume 140(2020)
• Publication Date: 2020-11
• Subjects: Neurodegenerative disorders -- Environmental toxins -- Antioxidant -- Inflammation -- Apoptosis; Neurochemistry -- Periodicals; Neurochemistry -- Periodicals; Neurochimie -- Périodiques; Neurochemistry; Periodicals; 612.804205
• DOI: 10.1016/j.neuint.2020.104823
• Languages: English
• ISSNs: 0197-0186

Abstract

Abstract: Lycopene is a naturally occurring carotenoid found abundantly in red fruits and vegetables. Myriads of literature documented potential health benefits of lycopene, owing to its sublime capacity of suppressing oxidative stress, inflammation, and modulation of various cell survival pathways. Due to its lipophilic nature, lycopene can reach brain adequately by traversing the blood-brain barrier thereby extending it's promising therapeutic benefits in neurological disorders. Lycopene efficiently assists in restoring the characteristic behavioural and pathophysiological changes associated with neurodegenerative disorders, epileptic conditions, aging, subarachnoid hemorrhage, spinal cord injury, and neuropathy. The detrimental impacts of environmental neurotoxins on brain and neuropathological consequences of consumption of high-lipid diet can also be mitigated by lycopene. Apart from its high antioxidant potency, lycopene confers neuroprotection by preventing proteinopathies, neuroinflammation, apoptosis, cerebral edema, and synaptic dysfunction. This review provides a lucid idea on the potential multi-faceted benefits of lycopene in disorders of the central nervous system and elucidates the molecular mechanisms and pathways of its action. Graphical abstract: Image 1 Highlights: Lycopene is a carotenoid with promising health benefits. Lycopene confers neuroprotection in neurodegenerative disorders, and toxin-induced neurotoxicity. Lycopene confers protection from high-lipid diet-induced toxic insults to brain. Lycopene ameliorates cognitive and psychomotor impairments. Ameliorates neuronal oxidative and inflammatory stress, mitochondrial dysfunction, and apoptosis.