3D printing integrated with controlled delivery for musculoskeletal tissue engineering. Issue 3 (July 2017)

• Record Type: Journal Article
• Authors: Tarafder, Solaiman; Lee, Chang H
• Is Part Of: Journal of 3D printing in medicine. Volume 1:Issue 3(2017)
• Page Start: 181
• Page End: 189
• Publication Date: 2017-07
• Subjects: 3D-printed scaffolds -- controlled delivery -- regenerative medicine -- tissue engineering; Three-dimensional imaging in medicine -- Periodicals; Three-dimensional printing -- Periodicals; Medical technology -- Periodicals; Medical innovations -- Periodicals; Biomedical Technology; Image Processing, Computer-Assisted; Medical innovations; Medical technology; Three-dimensional imaging in medicine; Three-dimensional printing; Periodicals; Electronic journals; Periodicals; 610.28
• DOI: 10.2217/3dp-2017-0005
• Languages: English
• ISSNs: 2059-4755

Abstract

3D printing is an emerging tool to fabricate scaffolds for tissue engineering and regenerative medicine, benefited by customized design, tunable internal microstructure and a wide range of applicable materials. As a recent technical advancement, 3D-printed scaffolds have been incorporated with a controlled delivery of growth factors and/or other bioactive cues to facilitate tissue regeneration, in addition to providing a temporal structural substrate for cell and tissue ingrowth. This review covers a number of the existing approaches to incorporate a controlled delivery system in 3D-printed scaffolds from hydrogel adsorption and surface coating to chemical integration and embedding microspheres. In addition, we discuss the advantages and disadvantages of each delivery method integrated in 3D-printed scaffolds, outstanding challenges and future directions.