Viscosity: An important factor in predicting the performance of submucosal injection materials. (October 2020)

• Record Type: Journal Article
• Authors: Yoshida, Takuma; Hirose, Ryohei; Naito, Yuji; Inoue, Ken; Dohi, Osamu; Yoshida, Naohisa; Kamada, Kazuhiro; Uchiyama, Kazuhiko; Ishikawa, Takeshi; Takagi, Tomohisa; Konishi, Hideyuki; Nakaya, Takaaki; Itoh, Yoshito
• Is Part Of: Materials & design. Volume 195(2020)
• Publication Date: 2020-10
• Subjects: Submucosal injection material -- Viscosity -- Shear rate -- Submucosal elevation height -- Injection pressure; EMR endoscopic mucosal resection -- ESD endoscopic submucosal dissection -- SIM submucosal injection material -- SEH submucosal elevation height -- IP injection pressure -- TNF thixotropic Newtonian fluid -- PF pseudoplastic fluid -- DX dextrose -- NaCl sodium chloride -- NS normal saline -- HA sodium hyaluronate -- SA sodium alginate -- HPMC hydroxypropyl methylcellulose -- SPA sodium polyacrylate -- XG xanthan gum -- CFD computational fluid dynamics -- IS injection speed; Materials -- Periodicals; Engineering design -- Periodicals; Matériaux -- Périodiques; Conception technique -- Périodiques; Electronic journals; 620.11
• DOI: 10.1016/j.matdes.2020.109008
• Languages: English
• ISSNs: 0264-1275

Abstract

Abstract: Viscous submucosal injection materials (SIMs) that are clinically used in endoscopic treatments for early gastrointestinal cancer and polyps contribute to the treatment effects. However, the relationship between SIM characteristics [such as injection pressure (IP) and submucosal elevation height (SEH)] and viscosity has not been evaluated. The aim of this study was to analyze this relationship and elucidate whether it is possible to predict the SIM characteristics by viscosity measurements. Viscosity, IP, and SEH of conventional and developing SIMs were measured, and the correlation between these values was evaluated. A newly developed measurement model accurately measured IP. The magnitude of IP increased as the endoscopic injection needle gauge, injection speed, and concentration of SIM were increased. The strongest correlations were observed between viscosity at a shear rate of 10 3 s −1 and IP (correlation coefficient > 0.9, p < .01) and between viscosity at a shear rate of 10 0 s −1 and the SEH (correlation coefficient > 0.9, p < .01). This study defined the viscosities that represent the SIM characteristics. These findings will contribute to the design and accelerate the development of suitable high-performance SIMs by eliminating complex characterization methods. Graphical abstract: Unlabelled Image Highlights: Focusing on viscosity is important for characterizing submucosal injection materials (SIMs) for endoscopic treatment of gastrointestinal tumors. Injection pressure (IP) correlated with the SIM viscosity at a shear rate of 10 3 s −1 . Submucosal elevation height (SEH) correlated with the SIM viscosity at a shear rate of 10 0 s −1 . SIM viscosity measurement can accurately predict IP and SEH, contributing to the development of high-performance SIM.