COVID-19: Pharmacology and kinetics of viral clearance. (November 2020)

• Record Type: Journal Article
• Authors: Farina, Nicola; Ramirez, Giuseppe A.; De Lorenzo, Rebecca; Di Filippo, Luigi; Conte, Caterina; Ciceri, Fabio; Manfredi, Angelo A.; Rovere-Querini, Patrizia
• Is Part Of: Pharmacological research. Volume 161(2020)
• Publication Date: 2020-11
• Subjects: COVID-19 -- SARS-CoV-2 -- Pharmacology -- Viral clearance kinetics; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2020.105114
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: Coronavirus Disease 2019 (COVID-19) is a pandemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical spectrum of COVID-19 is broad and varies from mild to severe forms complicated by acute respiratory distress and death. This heterogeneity might reflect the ability of the host immune system to interact with SARS-CoV2 or the characteristics of the virus itself in terms of loads or persistence. Information on this issue might derive from interventional studies. However, results from high-quality trials are scarce. Here we evaluate the level of evidence of available published interventional studies, with a focus on randomised controlled trials and the efficacy of therapies on clinical outcomes. Moreover, we present data on a large cohort of well-characterized patients hospitalized at a single University Hospital in Milano (Italy), correlating viral clearance with clinical and biochemical features of patients.