Role of nutraceuticals in cognition during aging and related disorders. (February 2021)

• Record Type: Journal Article
• Authors: Singh, Padmanabh; Sivanandam, Thamil Mani; Konar, Arpita; Thakur, M.K.
• Is Part Of: Neurochemistry international. Volume 143(2021)
• Publication Date: 2021-02
• Subjects: Aging -- Cognition -- Dementia -- Dietary supplements -- Nutrition -- Phytochemicals; Neurochemistry -- Periodicals; Neurochemistry -- Periodicals; Neurochimie -- Périodiques; Neurochemistry; Periodicals; 612.804205
• DOI: 10.1016/j.neuint.2020.104928
• Languages: English
• ISSNs: 0197-0186

Abstract

Abstract: Cognitive abilities are compromised with advancing age posing a great risk for the development of dementia and other related brain disorders. Genetic susceptibility as well as environmental exposures determine the fate of cognitive aging and its transition to pathological states. Emerging epidemiological and observational studies have revealed the importance of lifestyle factors including dietary patterns and nutritional intake in the maintenance of cognitive health and reducing the risk of neurodegenerative disorders. In this context, nutraceutical interventions have gained considerable attention in preventing age-related cognitive deficits and counteracting pathological processes. Nutraceuticals include dietary plants and derivatives, food supplements and processed foods with nutritional and pharmaceutical values. The present review highlights the importance of nutraceuticals in attenuating cognitive aging and its progression to dementia, with specific emphasis on chemical constituents, neurocognitive properties and mechanism of action. Highlights: Nutritional imbalance is a key risk factor for cognitive aging and disorders. Nutraceutical intervention delays cognitive aging and its progression to dementia. Nutraceuticals have antioxidant, anti-inflammatory and neuromodulatory properties.