An ionic gold(III)–zinc(II) pseudo-polymeric compound of [H3O][Au{S2CN(CH2)5}2]3[ZnCl4]2: Synthesis, supramolecular architecture and anti-tuberculosis activity. (1st November 2022)

• Record Type: Journal Article
• Authors: Loseva, Olga V.; Lutsenko, Irina A.; Rodina, Tatyana A.; Nelyubina, Yulia V.; Gerasimenko, Andrey V.; Bekker, Olga B.; Ivanov, Alexander V.; Eremenko, Igor L.
• Is Part Of: Polyhedron. Volume 226(2022)
• Publication Date: 2022-11-01
• Subjects: Pseudo-polymer ionic gold(III)–zinc(II) compound -- Dithocarbamato-chlorido complex -- Interionic secondary interactions -- Supramolecular self-assembly -- Anti-tuberculosis activity; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2022.116097
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: The crystal structure and supramolecular self-assembly involving numerous secondary (Au···S, S···Cl, Cl···Cl) interactions, as well as a high biological activity (against the non-pathogenic strain Mycolicibacterium smegmatis and virulent strains Mycobacterium tuberculosis H37Rv and CN-40) were successfully established for the newly prepared ionic complex of [H3 O][Au{S2 CN(CH2 )5 }2 ]3 [ZnCl4 ]2 . Abstract: An ionic Au(III)-Zn(II) dithiocarbamato-chlorido compound of [H3 O][Au{S2 CN(CH2 )5 }2 ]3 [ZnCl4 ]2 (1 ) has been synthesised by the reaction of binuclear zinc(II) pentamethylenedithiocarbamate with a H[AuCl4 ]/2.0 M HCl solution. The obtained complex was successfully characterised by FT-IR spectroscopy, elemental analysis and single-crystal X-ray diffraction. There are six ionic moieties in the unit cell of 1 : (i) three dithiocarbamato-gold(III) cations, one of which is structurally inequivalent to the other two; (ii) two symmetrically related tetrachloridozincate(II) anions and (iii) one hydronium cation that is disordered over four positions with equal occupancies of 0.25. The compound exhibits a rather complicated supramolecular structure, including pseudo-binuclear gold-rich [Au2 (S2 CNPm)4 ] 2+ cations and {[ZnCl4 ]2 } 4– counter anions, which are stabilised by secondary Au···S and Cl···Cl interactions, respectively. In turn, the former pseudo-binuclear formations involving centrosymmetric mononuclear cations of [Au(S2 CNPm)2 ] + give the pseudo-polymeric cationic chains of (···[Au2 (S2 CNPm)4 ] 2+ ···[Au(S2 CNPm)2 ] + ···) n ; while the latter, pseudo-binuclear zinc(II) anions, {[ZnCl4 ]2 } 4–, as the double linkers combine the neighbouring cationic chains yielding a two-dimensional pseudo-polymeric network. The results on the biological activity of 1 in vitro against the non-pathogenic strain Mycolicibacterium smegmatis (MIC 0.05 µg/disc) and virulent strains Mycobacterium tuberculosis H37Rv (0.14–0.19 µg/mL) and CN-40 (0.11–0.14 µg/mL) indicate a high efficiency of the studied Au(III)–Zn(II) compound against mycobacteria.