Cancer and SOX proteins: New insight into their role in ovarian cancer progression/inhibition. (November 2020)

• Record Type: Journal Article
• Authors: Ashrafizadeh, Milad; Taeb, Shahram; Hushmandi, Kiavash; Orouei, Sima; Shahinozzaman, Md.; Zabolian, Amirhossein; Moghadam, Ebrahim Rahmani; Raei, Mehdi; Zarrabi, Ali; Khan, Haroon; Najafi, Masoud
• Is Part Of: Pharmacological research. Volume 161(2020)
• Publication Date: 2020-11
• Subjects: OC ovarian cancer -- LAMA3 laminin subunit a3 -- USP39 ubiquitin-specific protease 39 -- HER3 human epidermal growth factor receptor 3 -- PI3K phosphatidylinositol 3-kinase -- SRY sox-determining region Y -- HMG high mobility group -- SOX sex-determining region Y (SRY)-related high-mobility group (HMG) box -- MMP matrix metalloproteinase -- EMT epithelial-to-mesenchymal transition -- KLF4 kruppel-like factor 4 -- miR microRNA -- CSCs cancer stem cells -- lncRNAs long non-coding RNAs -- ncRNAs non-coding RNAs -- PVT1 plasmacytoma variant translocation I -- HIF-1α hypoxia inducible factor-1α -- SNHG12 small nucleolar RNA host gene 12 -- PDGF platelet-derived growth factor -- YAP1 Yes associated protein 1 -- GLUT4 glucose transporter-4 -- TUBB3 βIII-tubulin -- PGD2 prostaglandin D2 -- ATG10 autophagy-related gene 10; SOX -- Transcription factor -- Ovarian cancer -- Cancer therapy -- Chemotherapy -- MicroRNA; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2020.105159
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: Transcription factors are potential targets in disease therapy, particularly in cancer. This is due to the fact that transcription factors regulate a variety of cellular events, and their modulation has opened a new window in cancer therapy. Sex-determining region Y (SRY)-related high-mobility group (HMG) box (SOX) proteins are potential transcription factors that are involved in developmental processes such as embryogenesis. It has been reported that abnormal expression of SOX proteins is associated with development of different cancers, particularly ovarian cancer (OC). In the present review, our aim is to provide a mechanistic review of involvement of SOX members in OC. SOX members may suppress and/or promote aggressiveness and proliferation of OC cells. Clinical studies have also confirmed the potential of transcription factors as diagnostic and prognostic factors in OC. Notably, studies have demonstrated the relationship between SOX members and other molecular pathways such as ST6Ga1-I, PI3K, ERK and so on, leading to more complexity. Furthermore, SOX members can be affected by upstream mediators such as microRNAs, long non-coding RNAs, and so on. It is worth mentioning that the expression of each member of SOX proteins is corelated with different stages of OC. Furthermore, their expression determines the response of OC cells to chemotherapy. These topics are discussed in this review to shed some light on role of SOX transcription factors in OC.