Exploring Bacteroidetes: Metabolic key points and immunological tricks of our gut commensals. Issue 7 (July 2018)

• Record Type: Journal Article
• Authors: Gibiino, Giulia; Lopetuso, Loris Riccardo; Scaldaferri, Franco; Rizzatti, Gianenrico; Binda, Cecilia; Gasbarrini, Antonio
• Is Part Of: Digestive and liver disease. Volume 50:Issue 7(2018)
• Page Start: 635
• Page End: 639
• Publication Date: 2018-07
• Subjects: Gut microbiota -- Molecular mimicry -- Metabolic syndrome -- Neurologic disorders; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2018.03.016
• Languages: English
• ISSNs: 1590-8658

Abstract

Abstract: Bacteroidetes are the largest phylum of Gram-negative bacteria inhabiting our gastrointestinal tract and are considered the leading players of the healthy state and sophisticated homeostasis safeguarded by gut microbiota. Furthermore, specific roles have been attributed to some Bacteroidetes genera in the development of immune dysregulation, systemic disease such as metabolic syndrome and also neurological disorders. Glycoproteins secretion, short fatty acids imbalance, toxins production and molecular mimicry are only a part of the functions exerted by these commensals interacting with the host. The aim of this review is to summarize the current knowledge on the recognized role of Bacteroidetes in physiological functions and pathological networks in order to define the needs for future research and clarify the potential role for targeted microbial therapies.