Unraveling molecular mechanisms of head and neck cancer. (October 2022)

• Record Type: Journal Article
• Authors: Antra, ; Parashar, Palak; Hungyo, Hungharla; Jain, Anuja; Ahmad, Shandar; Tandon, Vibha
• Is Part Of: Critical reviews in oncology/hematology. Volume 178(2022)
• Publication Date: 2022-10
• Subjects: APOBEC Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide -- CAF Cancer-associated fibroblasts -- CCR10 Chemokine receptor 10 -- CLNK Cytokine-dependent hematopoietic cell linker -- COX-2 Cyclooxygenase-2 -- CYP1A1 Cytochrome p450 family 1 subfamily A member1 -- DTH Delayed-type hypersensitivity -- ECM Extracellular matrix -- GLOBOCAN Global Cancer Observatory -- GST Glutathione S-transferase -- HNSCC Head and neck squamous cell carcinoma -- HPV Human papillomavirus -- IARC International Agency for Research on Cancer -- MDSC Myeloid-derived suppressor cell -- MFSD7 Major facilitator superfamily domain containing protein 7 -- MTHFD1L Methylenetetrahydrofolate dehydrogenase 1 -- MMP Matrix metalloproteinase -- NAB N′-Nitrosoanabasine -- NNAL 4-(Methylnitrosamino)− 1-(3-pyridyl)− 1- butanol -- NNK 4-(Methylnitrosamino)− 1-(3-pyridyl)- 1-butanone (NNK) -- NNN N′-Nitrosonornicotine -- OR Odds ratio -- OSCC Oral Squamous Cell Carcinoma -- SLAMF1 Signalling lymphocytic activation molecule family member 1 -- SLT Smokeless tobacco -- SNP Single nucleotide polymorphism -- TAM Tumour-associated macrophages -- TCGA The Cancer Genome Atlas -- TGF-β Tumor Growth factor-β -- TIMP Tissue inhibitor of metalloproteinase -- TKT Transketolase -- TME Tumour microenvironment -- TNF-α Tumor necrosis factor-α -- TNFRSF4 Tumour necrosis factor receptor superfamily, member 4 -- TSNA Tobacco-specific N-nitrosamines; HNSCC -- Smokeless tobacco -- Somatic mutation -- Single nucleotide variation -- OSCC -- TSCC -- GB-OSCC -- HPV; Oncology -- Periodicals; Hematology -- Periodicals; 616.994
• DOI: 10.1016/j.critrevonc.2022.103778
• Languages: English
• ISSNs: 1040-8428

Abstract

Abstract: Malignancies that develop from mucosal epithelium of the upper aerodigestive tract are known as head and neck squamous cell carcinomas (HNSCC). Heterogeneity, late stage diagnosis and high recurrence rate are big hurdles in head and neck treatment regimen. Presently, the biomarkers available for diagnosis and prognosis of HNSCC are based on smoking as the major risk habit. This review shed light on the differential environment of HNSCC in smokeless tobacco consuming Indian patients. Frequent mutation in genes involved in DNA repair pathway (p53), cell proliferation (PIK3CA, HRAS) and cell death (CASP8, FADD) are common in western population. On the contrary, the genes involved in metastasis (MMPs, YAP1), lymphocyte proliferation (TNFRSF4, CD80), cell-cell adhesion (DCC, EDNRB), miRNA processing (DROSHA) and inflammatory responses (TLR9, IL-9) are mutated in Indian HNSCC patients. Gene ontology enrichment analysis highlighted that responses to chemical stimulus, immune pathways and stress pathways are highly enriched in Indian patients. Highlights: The altered cellular pathways in HNSCC based on genomic signatures are presented. Gene ontology enrichment map is generated to compare the whole transcriptomics data from Indian datasets vs TCGA datasets. Genome wide methylation pattern between the Indian and Western cohorts are different. Response to chemical processes, stress, immune response pathways, and cytoskeleton assembly were enriched in Indian datasets. A link of genetic polymorphism in immune genes and response to tobacco exposure is explained.