Shedding light on current trends in molecular optogenetics. (October 2022)

• Record Type: Journal Article
• Authors: Fischer, Alexandra A.M.; Kramer, Markus M.; Radziwill, Gerald; Weber, Wilfried
• Is Part Of: Current opinion in chemical biology. Volume 70(2022)
• Publication Date: 2022-10
• Subjects: Extracellular optogenetics -- Liquid–liquid phase separation -- Molecular photoswitches -- Non-opsin-based optogenetics; Bioorganic chemistry -- Periodicals; Biology -- Periodicals; Biochemistry -- Periodicals; Clinical biochemistry -- Periodicals; Biochemistry -- Periodicals; Chimie bio-organique -- Périodiques; Biologie -- Périodiques; 572.05
• DOI: 10.1016/j.cbpa.2022.102196
• Languages: English
• ISSNs: 1367-5931

Abstract

Abstract: Molecular optogenetics is a highly dynamic research field. In the past two years, the field was characterized by the development of new allosteric switches as well as the forward integration of optogenetics research towards application. Further, two areas of research have significantly gathered momentum, the use of optogenetics to control liquid–liquid phase separation as well as the application of optogenetic tools in the extracellular space. Here, we review these areas and discuss future directions.