T helper profile in pregnant women recovered from COVID-19. (September 2022)

• Record Type: Journal Article
• Authors: Tartaglia, Eleonora; Bordoni, Veronica; Oliva, Alessandra; Vergori, Alessandra; Girardi, Enrico; Antinori, Andrea; Agrati, Chiara; Liuzzi, Giuseppina
• Is Part Of: Journal of reproductive immunology. Volume 153(2022)
• Publication Date: 2022-09
• Subjects: T helper cells -- Pregnancy -- COVID-19; Reproduction -- Immunological aspects -- Periodicals; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Reproduction -- Periodicals; Reproduction -- Immunologie -- Périodiques; Immunologie -- Périodiques; Immunology; Reproduction -- Immunological aspects; Periodicals; Electronic journals; Electronic journals; 615.766
• DOI: 10.1016/j.jri.2022.103661
• Languages: English
• ISSNs: 0165-0378

Abstract

Abstract: T helper (Th) cell subsets play distinct and important roles during pregnancy. This work was focused on investigating the Th and cytokine profile in pregnant women recovered from COVID-19. To this aim, the frequency of Th1, Th2, Th17 subsets and the level of associated cytokines were analysed in pregnant women recovered from COVID-19 and in matched non-pregnant women. Principal component analysis highlighted a significant impact of pregnancy on Th profile with an increase of ex-Th17 subset and a parallel decrease of Th1 population. These modulations may participate in both preserving the pregnancy and reducing the risk of severe infection.