Understanding main pregnancy complications through animal models. (September 2022)

• Record Type: Journal Article
• Authors: Aslanian-Kalkhoran, Lida; Esparvarinha, Mojgan; Nickho, Hamid; Aghebati-Maleki, Leili; Heris, Javad Ahmadian; Danaii, Shahla; Yousefi, Mehdi
• Is Part Of: Journal of reproductive immunology. Volume 153(2022)
• Publication Date: 2022-09
• Subjects: Animal models -- Pregnancy complications -- Recurring Pregnancy failure -- Recurring Implantation loss -- Preeclampsia; Reproduction -- Immunological aspects -- Periodicals; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Reproduction -- Periodicals; Reproduction -- Immunologie -- Périodiques; Immunologie -- Périodiques; Immunology; Reproduction -- Immunological aspects; Periodicals; Electronic journals; Electronic journals; 615.766
• DOI: 10.1016/j.jri.2022.103676
• Languages: English
• ISSNs: 0165-0378

Abstract

Abstract: Since human pregnancy is an inefficient process, achieving desired and pleasant outcome of pregnancy – the birth of a healthy and fit baby – is the main goal in any pregnancy. Spontaneous pregnancy failure is actually the most common complication of pregnancy and Most of these pregnancy losses are not known. Animal models have been utilized widely to investigate the system of natural biological adaptation to pregnancy along with increasing our comprehension of the most important hereditary and non-hereditary factors that contribute to pregnancy disorders. We use model organisms because their complexity better reproduces the human condition. A useful animal model for the disease should be pathologically similar to the disease conditions in humans. Animal models deserve a place in research because of the ethical limitations that apply to pregnant women's experiments. The present review provides insights into the overall risk factors involved in recurrent miscarriage, recurrent implant failure and preeclampsia and animal models developed to help researchers identify the source of miscarriage and the best research and treatment strategy for women with Repeated miscarriage and implant failure. Highlights: Having looked main pregnancy flaws through animal models. The link between animal models and reproductive disorders. Pregnancy complications, was signific in the last two decades. New animal models are a good way to identify the causes of infertility.