Clinical characterisation of patients in the post-acute stage of anti-NMDA receptor encephalitis: a prospective cohort study and comparison with patients with schizophrenia spectrum disorders. Issue 10 (October 2022)

• Record Type: Journal Article
• Authors: Guasp, Mar; Rosa-Justicia, Mireia; Muñoz-Lopetegi, Amaia; Martínez-Hernández, Eugenia; Armangué, Thais; Sugranyes, Gisela; Stein, Heike; Borràs, Roger; Prades, Laia; Ariño, Helena; Planagumà, Jesús; De-La-Serna, Elena; Escudero, Domingo; Llufriu, Sara; Sánchez-Valle, Raquel; Santamaria, Joan; Compte, Albert; Castro-Fornieles, Josefina; Dalmau, Josep; Páramo, Dolores; Medrano, Vicente; Casado, Virginia; Guanyabens, Nicolau; Giné-Servén, Eloi; Ángeles del Real, María; Pardo, Javier; Martin-Gil, Leticia; Barrero-Hernández, Francisco Javier; García-Barragán, Nuria; Falip, Mercè; Simó, Marta; Rodríguez, Eloy; Ruiz Ezquerro, Juan José; Bataller, Luis; Safont, Gemma; Vicente-Hervàs, José; Brieva, Luis; Casado, Ignacio; Portilla, Juan Carlos; Escalante, Sònia; Arenillas, Juan Francisco; Erro, Elena; Jericó-Pascual, Ivonne; Fuerte-Hortigón, Alejandro; Morató, Alba; Saiz, Albert; Blanco, Yolanda; Sepúlveda, Maria; Ruiz, Raquel; Naranjo, Laura; Rodés, Maria; Aguilar, Esther; Alba, Mercè; Caballero, Eva;
• Is Part Of: Lancet neurology. Volume 21:Issue 10(2022)
• Page Start: 899
• Page End: 910
• Publication Date: 2022-10
• Subjects: Neurology -- Periodicals; Neurology -- Periodicals; Nervous System Diseases -- Periodicals; Neurologie -- Périodiques; Neurology; Electronic journals; Periodicals; 616.805
• DOI: 10.1016/S1474-4422(22)00299-X
• Languages: English
• ISSNs: 1474-4422

Abstract

Summary: Background: Anti-NMDA receptor (NMDAR) encephalitis is associated with a post-acute stage that is not well known. We aimed to describe the clinical features of this stage, similarities with schizophrenia spectrum disorders, and the factors that predict cognitive–psychiatric outcomes and could serve as prognostic biomarkers. Methods: In this prospective cohort study, participants (aged 12–60 years) with anti-NMDAR encephalitis during the post-acute stage visited Hospital Clínic de Barcelona (Barcelona, Spain) on three occasions (at study entry [V1], at 6 months [V2], and at 12 months [V3]) and underwent comprehensive neuropsychiatric evaluations. Similar evaluations were done in a group of age-matched participants with schizophrenia spectrum disorders and a group of age-matched and sex-matched healthy participants also recruited from Hospital Clínic de Barcelona. We analysed differences between and within groups in the longitudinal follow-up using multilevel linear mixed-effect models, adjusting for group, age, sex, and socioeconomic status to control for possible confounding. Findings: Between Jan 1, 2017, and Sept 30, 2020, 82 participants were recruited, 28 (34%) with anti-NMDAR encephalitis, 27 (33%) with schizophrenia spectrum disorders, and 27 (33%) healthy participants. Although, by V1 (median 4 months [IQR 3–7] from disease onset), many acute-stage symptoms in participants with anti-NMDAR encephalitis had resolved (acute stage median modified Rankin Scale [mRS] score 5 [IQR 4–5] vs V1 mRS score 2 [1–2]; p<0·0001), 25 (89%) participants showed deficits in at least one cognitive domain. In this group, 15 (68%) of 22 cognitive domain variables were impaired at V1, whereas only eight (36%) were altered at V3 (p=0·016). In participants with schizophrenia spectrum disorders, 11 (50%) of 22 variables (all shared with participants with anti-NMDAR encephalitis) were impaired at V1, without changes at V3. Two acute-stage features of anti-NMDAR encephalitis (ie, decreased consciousness and no improvement within the first 4 weeks of treatment) predicted cognitive domain outcomes, and a visuospatial task (ie, serial biases) at V1 showed potential in predicting learning and memory outcomes. At V1, all psychiatric symptom clusters were similarly altered in participants with anti-NMDAR encephalitis and in those with schizophrenia spectrum disorders, but only those in individuals with anti-NMDAR encephalitis subsequently improved (p=0·031). The greatest cognitive–psychiatric improvement in participants with anti-NMDAR encephalitis occurred between V1 and V2. During this interval, four (14%) participants with anti-NMDAR encephalitis would have met the diagnostic criteria of schizophrenia if CSF antibody findings had not been investigated. Interpretation: The cognitive–psychiatric symptoms of anti-NMDAR encephalitis in the post-acute stage resembled those of stabilised schizophrenia, but only those in participants with anti-NMDAR encephalitis progressively improved, predominantly during V1–V2. These findings are important for clinical trials on anti-NMDAR encephalitis and suggest that prompt cognitive–psychosocial rehabilitation might be a valuable intervention. Funding: Instituto Salud Carlos III, NEURON Network of European Funding for Neuroscience Research, National Alliance for Research in Schizophrenia and Affective Disorders, and la Caixa Health-Research Foundation.